Zhang Kun, Zeng Min, Li Ye-Juan, Wu Hong-Fei, Wu Jin-Cai, Zhang Zhen-Sheng, Zheng Jin-Fang, Lv Yun-Fu
Department of Geriatric Center, Hainan General Hospital, Haikou 570311, Hainan Province, China.
Reproductive Medicine Center, Maternal and Child Health Care Hospital of Hainan Province, Haikou 570311, Hainan Province, China.
World J Clin Cases. 2022 Dec 26;10(36):13208-13215. doi: 10.12998/wjcc.v10.i36.13208.
Hypersplenism associated with cirrhotic portal hypertension is a common condition often resulting from hepatitis B-related cirrhosis. However, the levels of immunoglobulin (Ig) and complement in patients with hypersplenism associated with cirrhotic portal hypertension remain unclear. This study was undertaken to determine the levels of Ig and complement in these patients, the relationship between these levels and Child-Pugh class and their clinical significance.
To investigate the antibody (Ig) and complement levels in patients with hypersplenism associated with cirrhotic portal hypertension and their clinical significance.
Clinical data of 119 patients with hypersplenism associated with cirrhotic portal hypertension were statistically analyzed and compared with those of 128 control patients.
IgA and IgG levels in patients with hypersplenism were significantly higher than controls ( < 0.001). There was no significant difference in IgM between the two groups ( = 0.109). C3 and C4 levels in patients with hypersplenism were significantly lower than controls ( < 0.001). As liver function decreased, IgA and IgG levels increased ( < 0.001), and C3 and C4 levels decreased ( < 0.001).
Patients with hypersplenism associated with cirrhotic portal hypertension have significantly higher antibody (IgA and IgG) levels and significantly lower complement (C3 and C4) levels, which are both related to liver damage. Clinically, the administration of anti-hepatitis virus agents and protection of liver function should be strengthened.
与肝硬化门静脉高压相关的脾功能亢进是一种常见病症，常由乙型肝炎相关肝硬化引起。然而，与肝硬化门静脉高压相关的脾功能亢进患者的免疫球蛋白（Ig）和补体水平仍不清楚。本研究旨在确定这些患者的Ig和补体水平、这些水平与Child-Pugh分级之间的关系及其临床意义。
探讨与肝硬化门静脉高压相关的脾功能亢进患者的抗体（Ig）和补体水平及其临床意义。
对119例与肝硬化门静脉高压相关的脾功能亢进患者的临床资料进行统计分析，并与128例对照患者的资料进行比较。
脾功能亢进患者的IgA和IgG水平显著高于对照组（<0.001）。两组间IgM无显著差异（=0.109）。脾功能亢进患者的C3和C4水平显著低于对照组（<0.001）。随着肝功能下降，IgA和IgG水平升高（<0.001），C3和C4水平下降（<0.001）。
与肝硬化门静脉高压相关的脾功能亢进患者的抗体（IgA和IgG）水平显著升高，补体（C3和C4）水平显著降低，两者均与肝损伤有关。临床上，应加强抗肝炎病毒药物的应用和肝功能的保护。
