Flores Michael William, Granados Saul, Cook Benjamin Lê
Health Equity Research Lab, Cambridge Health Alliance, Cambridge, MA, United States.
Department of Psychiatry, Harvard Medical School, Boston, MA, United States.
Front Psychiatry. 2023 Jan 5;13:1057784. doi: 10.3389/fpsyt.2022.1057784. eCollection 2022.
In the US over the past decade, there has been a steady increase in marijuana use rates among adolescents, in part due to marijuana legalization laws. It is unknown whether these greater marijuana use rates are associated with rising rates of adolescent suicide ideation and behaviors (plan and attempt) or whether these associations differ by gender or race/ethnicity.
To determine whether marijuana use is associated with suicide ideation/behaviors among adolescents and if differences exist by gender and race/ethnicity.
Using the 2015-2019 National Surveys on Drug Use and Health, we assessed the relationship between marijuana use frequency and suicide ideation/behaviors among adolescents (12-17, = 73,986). We also examined the association with marijuana use disorder (MUD) and assessed differences by gender and race/ethnicity. Marijuana use frequency in the past year was categorized as no use, non-weekly use, and weekly-plus use. We estimated multivariable logistic regression models, adjusting for sociodemographics, health status, common co-occurring behavioral health disorders, and criminal history. For interpretability, regression coefficients were converted into predicted probabilities using predictive margin methods.
In primary analyses, adolescents with non-weekly use and weekly-plus use had higher rates of any suicide ideation, 61.5% (+ 10.4 percentage-points; 95% CI: 7.0-13.8%) and 64.5% (+ 13.4 percentage-points; 95% CI: 9.1-17.7%), relative to no use (51.1%). Non-weekly and weekly-plus use was associated with higher rates of any suicide plan 58.2% (+ 11.8 percentage-points; 95% CI: 7.8-16.0%) and 59.0% (+ 12.6 percentage-points; 95% CI: 6.4-18.9%), and any suicide attempt, 42.0% (+ 11.6 percentage-points; 95% CI: 7.0-16.2%) and 47.3% (+ 16.9 percentage-points; 95% CI: 10.9-22.9%) compared to no use (46.4 and 30.4%, respectively). Similar results were found among adolescents with a MUD (all < 0.05). Positive associations between marijuana use and suicide ideation/behaviors persisted among males and females as well as White, Black, and Latinx adolescents (all < 0.05).
Between 2015 and 2019, suicide ideation/behaviors increased for adolescents that used marijuana. As marijuana is legalized in more states, public health efforts are needed to curb increases in marijuana use among adolescents and to better understand the causal linkages between marijuana use and suicide ideation/behaviors.
在过去十年的美国,青少年使用大麻的比率稳步上升,部分原因是大麻合法化法律。目前尚不清楚这些更高的大麻使用率是否与青少年自杀意念和行为(计划和尝试)的上升率相关,或者这些关联是否因性别或种族/民族而异。
确定青少年使用大麻是否与自杀意念/行为相关,以及性别和种族/民族之间是否存在差异。
利用2015 - 2019年全国药物使用和健康调查,我们评估了青少年(12 - 17岁,n = 73,986)中大麻使用频率与自杀意念/行为之间的关系。我们还研究了与大麻使用障碍(MUD)的关联,并评估了性别和种族/民族之间的差异。过去一年的大麻使用频率分为未使用、非每周使用和每周及以上使用。我们估计了多变量逻辑回归模型,并对社会人口统计学、健康状况、常见的共病行为健康障碍和犯罪史进行了调整。为了便于解释,使用预测边际方法将回归系数转换为预测概率。
在主要分析中,与未使用大麻(51.1%)相比,非每周使用和每周及以上使用大麻的青少年出现任何自杀意念的比率更高,分别为61.5%(+10.4个百分点;95%CI:7.0 - 13.8%)和64.5%(+13.4个百分点;95%CI:9.1 - 17.7%)。非每周使用和每周及以上使用大麻与任何自杀计划的更高比率相关,分别为58.2%(+11.8个百分点;95%CI:7.8 - 16.0%)和59.0%(+12.6个百分点;95%CI:6.4 - 18.9%),以及任何自杀尝试的更高比率,分别为42.0%(+11.6个百分点;95%CI:7.0 - 16.2%)和47.3%(+16.9个百分点;95%CI:10.9 - 22.9%),而未使用大麻的青少年自杀计划和自杀尝试的比率分别为46.4%和30.4%。在患有MUD的青少年中也发现了类似结果(所有p < 0.05)。大麻使用与自杀意念/行为之间的正相关在男性和女性以及白人、黑人和拉丁裔青少年中均持续存在(所有p < 0.05)。
在2015年至2019年期间,使用大麻的青少年自杀意念/行为有所增加。随着更多州将大麻合法化,需要开展公共卫生工作来遏制青少年中大麻使用的增加,并更好地理解大麻使用与自杀意念/行为之间的因果联系。