He Dingxiu, Yang Yong, Yang Yi, Tang Xiaoqu, Huang Kaisen
Department of Emergency, Deyang People's Hospital, Sichuan, China.
Department of Cardiology, Deyang People's Hospital, Sichuan, China.
Front Surg. 2023 Jan 6;9:1056795. doi: 10.3389/fsurg.2022.1056795. eCollection 2022.
We aimed to assess whether C-reactive protein to albumin ratio (CAR) is associated with the clinicopathology and prognosis of patients with non-small cell lung cancer (NSCLC) after surgery.
Several literature databases were searched for eligible studies in English and Chinese published before September 1, 2022, according to the inclusion and exclusion criteria. The pooled odds ratios (ORs) with 95% confidence interval (CI) were calculated to assess the association of CAR in lung cancer with clinicopathological characteristics including age, sex, smoking status, lymph node metastasis, and American Association of Cancer (AJCC) stage. The pooled hazard ratios (HRs) with 95% CI were calculated to assess the association of CAR with prognosis in lung cancer. Publication bias was assessed using Egger's test.
Overall, 9 studies involving 3,359 NSCLC patients were included in this meta-analysis. The CAR was observed to be higher in males, smokers, and patients with lymph node metastasis and correlated with advanced AJCC stage but not with age. Moreover, a high CAR correlated with poor survival. No publication bias was observed in this meta-analysis.
CAR was observed to be a significant biomarker for prognosis and associated with clinicopathological characteristics in patients with NSCLC after surgery.
我们旨在评估C反应蛋白与白蛋白比值（CAR）是否与非小细胞肺癌（NSCLC）患者术后的临床病理特征及预后相关。
根据纳入和排除标准，检索了几个文献数据库，以查找2022年9月1日前发表的符合条件的中英文研究。计算合并比值比（OR）及95%置信区间（CI），以评估肺癌中CAR与临床病理特征（包括年龄、性别、吸烟状况、淋巴结转移及美国癌症联合委员会（AJCC）分期）之间的关联。计算合并风险比（HR）及95%CI，以评估CAR与肺癌预后之间的关联。采用Egger检验评估发表偏倚。
总体而言，本荟萃分析纳入了9项研究，共3359例NSCLC患者。观察发现，男性、吸烟者、有淋巴结转移的患者CAR较高，且与AJCC晚期相关，但与年龄无关。此外，高CAR与生存不良相关。本荟萃分析未观察到发表偏倚。
观察发现，CAR是NSCLC患者术后预后的重要生物标志物，并与临床病理特征相关。
