不同种族及孟加拉女性中乳腺癌亚型的患病率：人口统计学、临床病理及综合癌症信息学分析

Prevalence of Breast Cancer Subtypes Among Different Ethnicities and Bangladeshi Women: Demographic, Clinicopathological, and Integrated Cancer Informatics Analysis.

作者信息

Islam Diganta, Islam Md Shihabul, Dorin Sanjida Islam

机构信息

Department of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka, Bangladesh.

Department of Genetic Engineering & Biotechnology, University of Rajshahi, Rajshahi, Bangladesh.

出版信息

Cancer Inform. 2023 Jan 17;22:11769351221148584. doi: 10.1177/11769351221148584. eCollection 2023.

DOI:10.1177/11769351221148584

PMID:36684416

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9850134/

Abstract

BACKGROUND

The molecular subtyping of breast cancer is related to estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). The present study aimed to systematically analyze the expression, function, and prognostic value of ER, PR, HER2, and their prevalence in different ethnic groups and among Bangladeshi breast cancer (BC) patients.

METHOD

This study included 25 BC patients and 25 healthy controls, aged between 25 and 70 years. The study characteristics were compared using the ANOVA and Chi-square tests. Also, the multi-Omics dataset of 775 BC patients from TCGA was analyzed for ER, PR, and HER2 in breast cancer subtypes and compared among different ethnicities.

RESULTS

For most BD breast cancer cases, the age at diagnosis was ⩾40 years, had only a histopathological diagnosis (-value .004), and no history of mammography or other pathological tests. For treatment, had only chemotherapy (-value .004) and no hormone therapy (-value <.001). The majority of patients (>60%) were of stage-II cancer and TNBC (40%) subtype. The BC ethnicity-stratified data of ER, PR, and HER2 indicated a strong correlation across all ethnicities (-value 4.99e-35; -value 3.79e-18). The subtypes stratified data indicated a higher percentage of Luminal A (58.3%) in Caucasians whereas Luminal B (24.3%) and HER2 (25.2%) subtypes were found higher in Asians and TNBC (36.0%) were found in Africans. However, a significantly higher frequency of TNBC (52.2%) compared to Asians (14.8%) was found in BD patients (-value <.001). The overall survival analysis of BC subtypes demonstrated that Luminal B (-value .005) and HER2 enriched (-value .015) were significantly more aggressive and were dominant in the Asian population.

CONCLUSION

A significant association was found between BC subtypes with different ethnicities and Bangladeshi women and these findings might aid in the prevention, management, and raising of awareness against risk factors in the near future.

摘要

背景

乳腺癌的分子亚型与雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2（HER2）有关。本研究旨在系统分析ER、PR、HER2的表达、功能和预后价值，以及它们在不同种族和孟加拉国乳腺癌（BC）患者中的患病率。

方法

本研究纳入了25例BC患者和25例健康对照，年龄在25至70岁之间。使用方差分析和卡方检验比较研究特征。此外，还分析了来自TCGA的775例BC患者的多组学数据集，以了解乳腺癌亚型中的ER、PR和HER2，并在不同种族之间进行比较。

结果

对于大多数孟加拉国乳腺癌病例，诊断年龄≥40岁，仅有组织病理学诊断（P值=0.004），且无乳腺X线摄影或其他病理检查史。在治疗方面，仅有化疗（P值=0.004），无激素治疗（P值<0.001）。大多数患者（>60%）为II期癌症和三阴性乳腺癌（TNBC，40%）亚型。ER、PR和HER2的BC种族分层数据表明，所有种族之间存在很强的相关性（P值=4.99×10⁻³⁵；P值=3.79×10⁻¹⁸）。亚型分层数据表明，白种人中Luminal A亚型的比例较高（58.3%），而亚洲人中Luminal B亚型（24.3%）和HER2亚型（25.