Xiong Nating, Han Wendao, Yu Zhikang
Department of Blood Transfusion, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, People's Republic of China.
Institute of Basic Medical Sciences, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, People's Republic of China.
Int J Gen Med. 2024 Oct 23;17:4823-4833. doi: 10.2147/IJGM.S486873. eCollection 2024.
Lymph node metastasis (LNM) is an important prognostic factor for breast cancer. Inflammatory stimulation can change tumor microenvironment and lead to LNM, but the relationship between LNM and peripheral immunoinflammatory indices has not been clarified in breast cancer.
The clinical information of 1918 patients with breast cancer admitted to Meizhou People's Hospital from October 2017 to December 2023 were retrospectively analyzed. The relationship of clinicopathological features (age, body mass index (BMI), ABO blood types, family history of cancer, tumor site, disease stage, LNM, distant metastasis, and molecular subtypes) and peripheral immunoinflammatory indices (pan-immune inflammation value (PIV), systemic immune inflammation index (SII), and system inflammation response index (SIRI)) were analyzed.
There were 935 (48.7%) patients had no LNM and 983 (51.3%) had LNM. There were statistically significant differences in the distributions of ABO blood groups (=0.022) and molecular subtypes (<0.001) between the two groups. PIV, SII, and SIRI levels in patients with LNM were significantly higher than those without LNM (all <0.05). The proportions of LNM in patients with high PIV, SII, and SIRI levels were higher than those with low PIV, SII, and SIRI levels, respectively. Logistic regression analysis showed that non-O blood type (non-O blood type vs O blood type, odds ratio (OR): 1.327, 95% confidence interval (CI): 1.056-1.667, =0.015), luminal B subtype (luminal B vs luminal A, OR: 2.939, 95% CI: 2.147-4.022, <0.001), HER2+ subtype (HER2+ vs luminal A, OR: 2.044, 95% CI: 1.388-3.009, <0.001), and high SIRI level (≥0.875 vs <0.875, OR: 1.572, 95% CI: 1.092-2.265, =0.015) were independently associated with LNM.
Non-O blood type, luminal B and HER2+ subtypes, and high SIRI level (≥0.875) have potential role in predicting the status of LNM in breast cancer patients.
淋巴结转移（LNM）是乳腺癌重要的预后因素。炎症刺激可改变肿瘤微环境并导致LNM，但乳腺癌中LNM与外周免疫炎症指标之间的关系尚未阐明。
回顾性分析2017年10月至2023年12月在梅州市人民医院住院的1918例乳腺癌患者的临床资料。分析临床病理特征（年龄、体重指数（BMI）、ABO血型、癌症家族史、肿瘤部位、疾病分期、LNM、远处转移和分子亚型）与外周免疫炎症指标（全免疫炎症值（PIV）、全身免疫炎症指数（SII）和全身炎症反应指数（SIRI））之间的关系。
935例（48.7%）患者无LNM，983例（51.3%）有LNM。两组间ABO血型分布（=0.022）和分子亚型分布（<0.001）存在统计学显著差异。有LNM患者的PIV、SII和SIRI水平显著高于无LNM患者（均<0.05）。PIV、SII和SIRI水平高的患者LNM比例分别高于PIV、SII和SIRI水平低的患者。Logistic回归分析显示，非O血型（非O血型与O血型，比值比（OR）：1.327，95%置信区间（CI）：1.056-1.6
