State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Eastern Clinic, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Front Immunol. 2023 Jan 4;13:1068186. doi: 10.3389/fimmu.2022.1068186. eCollection 2022.
The purpose of treating alveolar bone cleft is to restore a normal maxilla structure. Multiple factors have been identified that can affect the success of alveolar bone grafting. However, with consistent treatment modifications, the surgical outcomes have been improved, but alveolar bone loss still exists. Thus, a new aspect should be found to solve this problem. As alveolar bone belongs to the periodontal tissues, the mechanism of the alveolar bone loss after bone grafting in patients with alveolar bone cleft may be similar to the development of alveolar bone loss in periodontitis. Cell-free DNA (cfDNA) has been demonstrated as a key promoter of alveolar bone loss during periodontal inflammation. We hypothesized that cfDNA-related innate immune responses could be a major inducement for postoperative bone loss after alveolar bone grafting. In this perspective, we preliminarily proved the potential association between cfDNA, TLR9 pathway, and alveolar bone grafting operation, and it might verify that surgical trauma could accumulate cfDNA, which can further activate cellular TLR9 signaling.
治疗牙槽骨裂的目的是恢复正常的上颌结构。已经确定了多种因素会影响牙槽骨移植的成功率。然而，通过不断的治疗修改，手术结果得到了改善，但牙槽骨仍然存在流失。因此，需要找到一个新的方面来解决这个问题。由于牙槽骨属于牙周组织，牙槽骨裂患者骨移植后牙槽骨丢失的机制可能与牙周炎中牙槽骨丢失的发展相似。无细胞 DNA（cfDNA）已被证明是牙周炎炎症期间牙槽骨丢失的关键促进因素。我们假设 cfDNA 相关的先天免疫反应可能是牙槽骨移植术后骨丢失的主要诱因。从这个角度来看，我们初步证明了 cfDNA、TLR9 通路与牙槽骨移植手术之间的潜在关联，这可能证实手术创伤会积累 cfDNA，进一步激活细胞 TLR9 信号。
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