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Efficacy of pro-PAM (N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride) as a prophylaxis against organophosphate poisoning.

作者信息

Clement J G

出版信息

Toxicol Appl Pharmacol. 1979 Feb;47(2):305-11. doi: 10.1016/0041-008x(79)90325-9.

DOI:10.1016/0041-008x(79)90325-9
PMID:36686
Abstract
摘要

相似文献

1
Efficacy of pro-PAM (N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride) as a prophylaxis against organophosphate poisoning.
Toxicol Appl Pharmacol. 1979 Feb;47(2):305-11. doi: 10.1016/0041-008x(79)90325-9.
2
Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning in rodents.吡啶斯的明预处理降低阿托品和2-吡啶醛肟甲基氯铵对啮齿动物沙林和VX中毒的治疗效果。
Fundam Appl Toxicol. 1992 Jan;18(1):102-6. doi: 10.1016/0272-0590(92)90201-r.
3
Efficacy of Recommended Prehospital Human Equivalent Doses of Atropine and Pralidoxime Against the Toxic Effects of Carbamate Poisoning in the Hartley Guinea Pig.推荐的院前等效人用剂量阿托品和氯解磷定对哈特利豚鼠氨基甲酸酯中毒毒性作用的疗效
Int J Toxicol. 2016 May;35(3):344-57. doi: 10.1177/1091581816638086. Epub 2016 Apr 21.
4
[Is PAM an effective antidote for organophosphate poisoning? There is no evidence that PAM is effective in acute organophosphorus poisoning].解磷定是有机磷中毒的有效解毒剂吗？没有证据表明解磷定对急性有机磷中毒有效。
Chudoku Kenkyu. 2010 Mar;23(1):36-40.
5
The effects of atropine, pralidoxime, and lidocaine on nerve--muscle and respiratory function in organophosphate-treated rabbits.阿托品、解磷定和利多卡因对有机磷中毒家兔神经肌肉及呼吸功能的影响
Can J Physiol Pharmacol. 1970 Sep;48(9):625-30. doi: 10.1139/y70-092.
6
[Is PAM an effective antidote for organophosphate poisoning? Pros: PAM (pralidoxime) is effective for acute poisoning of organophosphorus].解磷定是有机磷中毒的有效解毒剂吗？优点：解磷定（派姆）对急性有机磷中毒有效。
Chudoku Kenkyu. 2010 Mar;23(1):31-5.
7
Improved delivery through biological membranes. 3. Delivery of N-methylpyridinium-2-carbaldoxime chloride through the blood-brain barrier in its dihydropyridine pro-drug form.通过生物膜实现的递送改善。3. 以二氢吡啶前药形式通过血脑屏障递送N-甲基吡啶-2-甲醛肟氯化物。
J Med Chem. 1976 Jan;19(1):113-7. doi: 10.1021/jm00223a019.
8
Is PAM an effective antidote for organophosphate poisoning?PAM（解磷定）是有机磷中毒的有效解毒剂吗？
Chudoku Kenkyu. 2010 Mar;23(1):30.
9
Overcoming inhibitions.克服抑制作用。
Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13263-4. doi: 10.1073/pnas.0606052103. Epub 2006 Aug 28.
10
Cardiac damage in acute organophosphate poisoning in rats: effects of atropine and pralidoxime.大鼠急性有机磷中毒时的心脏损害：阿托品和氯解磷定的作用
Am J Emerg Med. 2009 Feb;27(2):169-75. doi: 10.1016/j.ajem.2008.01.016.

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In vitro P-glycoprotein activity does not completely explain in vivo efficacy of novel centrally effective oxime acetylcholinesterase reactivators.
在体 P-糖蛋白活性不能完全解释新型中枢作用肟类乙酰胆碱酯酶重激活剂的体内疗效。
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Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates.用于重新激活被沙林和VX模拟物抑制的胆碱酯酶的新型脑穿透性肟类化合物。
Ann N Y Acad Sci. 2016 Jun;1374(1):52-8. doi: 10.1111/nyas.13053. Epub 2016 May 6.
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Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates.新型取代苯氧基烷基吡啶肟可提高接受致死剂量神经毒剂替代物的大鼠的存活率，并减轻其癫痫样行为。
Toxicology. 2016 Jan 2;339:51-57. doi: 10.1016/j.tox.2015.12.001. Epub 2015 Dec 17.
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An efficient in vitro assay for acetylcholinesterase reactivators using immobilized enzyme.一种使用固定化酶的乙酰胆碱酯酶重激活剂的有效体外测定法。
Pharm Res. 1984 May;1(3):115-20. doi: 10.1023/A:1016323919445.
7
Use of the 2-Pyridinealdoxime/N,N'-Donor Ligand Combination in Cobalt(III) Chemistry: Synthesis and Characterization of Two Cationic Mononuclear Cobalt(III) Complexes.使用 2-吡啶醛肟/N,N'-供体配体组合在钴(III)化学中的应用：两种阳离子单核钴(III)配合物的合成与表征。
Bioinorg Chem Appl. 2010;2010. doi: 10.1155/2010/159656. Epub 2010 Jul 18.
8
Comparison of several oximes on reactivation of soman-inhibited blood, brain and tissue cholinesterase activity in rats.几种肟类化合物对大鼠体内梭曼抑制的血液、脑和组织胆碱酯酶活性的重新激活作用比较。
Arch Toxicol. 1993;67(9):637-46. doi: 10.1007/BF01974071.
9
In vitro oxime-induced reactivation of various molecular forms of soman-inhibited acetylcholinesterase in striated muscle from rat, monkey and human.体外肟诱导大鼠、猴和人横纹肌中梭曼抑制的不同分子形式乙酰胆碱酯酶的重新激活。
Arch Toxicol. 1994;68(10):648-55. doi: 10.1007/BF03208345.
10
Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice.乙酰胆碱酯酶重活化剂HI-6与双复磷联合使用对小鼠塔崩和梭曼中毒的疗效。
Arch Toxicol. 1987;61(1):70-5. doi: 10.1007/BF00324551.