扎黑丹地区糖尿病患者颊黏膜细胞的细胞形态计量学评估与血糖状况（2019年）
Cytomorphometric Assessment of Buccal Mucosa Cells and Blood Sugar Status in Diabetic Patients in Zahedan (2019).
作者信息
Saravani Shirin, Karimkoshteh Azra, Samaei Rahni Majid, Kadeh Hamideh
机构信息
Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
Internal Medicine Department, Zahedan University of Medical Sciences, Zahedan, Iran.
出版信息
Med J Islam Repub Iran. 2021 Dec 18;35:168. doi: 10.47176/mjiri.35.168. eCollection 2021.
Diabetes mellitus is one of the major global health threats. Diabetes can cause adverse cytopathological changes in cells and predispose them to pathological lesions. The present study aimed to investigate the cytopathological changes of oral mucosal cells in type 1 and 2 diabetes patients and its relationship with blood sugar status. This study descriptive-analytical was performed on 40 type-1 diabetes patients, 40 type-2 diabetic patients, and 20 non-diabetic individuals (control group) with simple sampling in Zahedan (2019). Their buccal mucosa was sampled by a cytobrush and the microscope slides were prepared with Papanicolaou staining. The nuclear and cytoplasmic area and cytoplasmic-nuclear ratio were calculated. Furthermore, the relationship of hemoglobin A1C and fasting blood sugar with these parameters were also examined. Data was analyzed with one-way-ANOVA, Kruskal-Wallis, Post Hoc Tukey, Mann-Whitney, Pearson correlation and Spearman correlation tests. In this regard, the statistical software SPSS (version 21) was used and a p-value <0.05 was considered statistically significant. Based on the findings, only the nuclear area was significantly larger in type 1 and type 2 diabetes patients, compared to the control group (p<0.001 and p=0.010), respectively. Moreover, the comparison of cytomorphometric changes between type 1 and type 2 diabetes patients did not show a significant difference. In addition, the hemoglobin A1C levels were merely associated with the cytoplasmic area in type 2 diabetes patients (p=0.011), while fasting blood sugar levels were not associated with any of the parameters in type 1 and type 2 diabetes patients (p>0.050). Diabetes, as an independent factor, can cause cytomorphometric changes in the buccal mucosal cells of type 1 and type 2 diabetes patients. It seems that the type of diabetes does not affect these changes. hemoglobin A1C levels were correlated with cytoplasmic area in type 2 diabetes patients.
糖尿病是全球主要的健康威胁之一。糖尿病可导致细胞发生不良的细胞病理学变化，并使其易患病理病变。本研究旨在调查1型和2型糖尿病患者口腔黏膜细胞的细胞病理学变化及其与血糖状态的关系。本描述性分析研究于2019年在扎赫丹采用简单抽样法对40例1型糖尿病患者、40例2型糖尿病患者和20例非糖尿病个体（对照组）进行。通过细胞刷采集他们的颊黏膜样本，并用巴氏染色法制备显微镜载玻片。计算细胞核和细胞质面积以及细胞质与细胞核的比例。此外，还检查了糖化血红蛋白A1C和空腹血糖与这些参数的关系。数据采用单因素方差分析、Kruskal-Wallis检验、事后Tukey检验、Mann-Whitney检验、Pearson相关分析和Spearman相关分析进行分析。在此方面，使用了统计软件SPSS（版本21），p值<0.05被认为具有统计学意义。根据研究结果，与对照组相比，仅1型和2型糖尿病患者的细胞核面积显著更大（分别为p<0.001和p=0.010）。此外，1型和2型糖尿病患者之间细胞形态计量学变化的比较未显示出显著差异。此外，糖化血红蛋白A1C水平仅与2型糖尿病患者的细胞质面积相关（p=0.011），而空腹血糖水平与1型和2型糖尿病患者的任何参数均无关联（p>0.050）。糖尿病作为一个独立因素，可导致1型和2型糖尿病患者颊黏膜细胞发生细胞形态计量学变化。似乎糖尿病类型并不影响这些变化。2型糖尿病患者的糖化血红蛋白A1C水平与细胞质面积相关。
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