Wang Fengxiao, Peng Pinwei, Zheng Yixin, Cheng Shuqun, Chen Yunfei
Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Hepatobiliary Surgery, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Evid Based Complement Alternat Med. 2023 Jan 13;2023:3697223. doi: 10.1155/2023/3697223. eCollection 2023.
To evaluate the efficacy and safety of acupuncture compared to that of parecoxib sodium on postoperative pain (POP), postoperative nausea and vomiting (PONV), and the Bruggemann Comfort Scale (BCS) in patients following laparoscopic cholecystectomy (LC).
Eligible patients admitted to the hospital for LC were randomly allocated to either acupuncture or control groups in a 1 : 1 ratio. The subjects in the acupuncture group received acupuncture while those in the control group were injected by parecoxib sodium at their requests. The pain score, PONV score, and BCS were assessed at 0 h, 6 h, 9 h, and 12 h after operation. The primary outcome was the pain score. The secondary outcomes included the number of patients asking for parecoxib sodium from the two groups at 0-6 h and 6-12 h, PONV score, and BCS score.
The pain score of the acupuncture group were lower in acupuncture than that in the control group at 6 h and 9 h after operation (=0.002, =0.008). However, no difference was found at 12 h. Besides, the number of patients administered parecoxib sodium in acupuncture group was less than that in the control group both at 0-6 h and 6-12 h after operation (=0.019, < 0.001). Similarly, there were significantly lower levels of PONV score and higher levels of BCS at 6 h after operation in the acupuncture group than in the control group. However, no difference was found at 9 h and 12 h.
Acupuncture can clinically improve the short-term treatment of postoperative pain after LC and reduce the request for extra analgesics; therefore, acupuncture might be a potential method as one of multimodal analgesia techniques to treat POP following LC. . This trial is registered with ChiCTR2000036885 (Chinese Clinical Trial Registry).
评估与帕瑞昔布钠相比，针刺对腹腔镜胆囊切除术（LC）患者术后疼痛（POP）、术后恶心呕吐（PONV）及布鲁格曼舒适度量表（BCS）的疗效和安全性。
符合条件的因LC入院的患者按1∶1比例随机分为针刺组或对照组。针刺组患者接受针刺治疗，而对照组患者根据自身要求注射帕瑞昔布钠。分别在术后0小时、6小时、9小时和12小时评估疼痛评分、PONV评分及BCS。主要结局指标为疼痛评分。次要结局指标包括两组在0至6小时和6至12小时使用帕瑞昔布钠的患者数量、PONV评分及BCS评分。
术后6小时和9小时，针刺组的疼痛评分低于对照组（=0.002，=0.008）。然而，术后12小时未发现差异。此外，术后0至6小时和6至12小时，针刺组使用帕瑞昔布钠的患者数量少于对照组（=0.019，<0.001）。同样，术后6小时针刺组的PONV评分显著低于对照组，BCS评分则显著高于对照组。然而，9小时和12小时未发现差异。
针刺在临床上可改善LC术后疼痛的短期治疗，并减少额外镇痛药物的需求；因此，针刺可能是作为多模式镇痛技术之一治疗LC术后POP的一种潜在方法。本试验已在中国临床试验注册中心注册，注册号为ChiCTR2000036885。
