Suzuki E, Kurata T, Koda M, Arakawa N
Department of Food and Nutrition, Ochanomizu University, Tokyo, Japan.
J Nutr Sci Vitaminol (Tokyo). 1987 Jun;33(3):169-75. doi: 10.3177/jnsv.33.169.
The erythorbic acid (ErA) content in the tissues of guinea pigs administered ErA was compared with that of ascorbic acid (AsA). Guinea pigs were administered 1, 5, 20, and 100 mg ErA/day or 1, 5, and 100 mg AsA/day for 16 days and then sacrificed. The liver, adrenal glands, spleen, and kidneys were removed to determine the contents of ErA and AsA using HPLC. Only a small amount of ErA was found in four tissues of the animals administered 20 mg or more of ErA/day. On the contrary, AsA was found in the tissues of all animals administered 1 mg or more of AsA/day. The ErA content in the tissues was much lower than that of AsA even when the amount of ErA administered was the same as that of AsA. However, the body weight gains of animals administered ErA were similar to those of animals administered AsA. These observations suggested that the mechanism of the retention of ErA in the tissues was much different from that of AsA and that the vitamin C activity of ErA might be more than one-twentieth that of AsA.
将给予异抗坏血酸（ErA）的豚鼠组织中的异抗坏血酸（ErA）含量与抗坏血酸（AsA）的含量进行比较。给豚鼠每天分别给予1、5、20和100mg ErA或1、5和100mg AsA，持续16天，然后处死。取出肝脏、肾上腺、脾脏和肾脏，使用高效液相色谱法（HPLC）测定ErA和AsA的含量。在每天给予20mg或更多ErA的动物的四种组织中仅发现少量ErA。相反，在每天给予1mg或更多AsA的所有动物的组织中都发现了AsA。即使给予的ErA量与AsA量相同，组织中的ErA含量也远低于AsA。然而，给予ErA的动物的体重增加与给予AsA的动物相似。这些观察结果表明，ErA在组织中的保留机制与AsA有很大不同，并且ErA的维生素C活性可能是AsA的二十分之一以上。
