Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Int J Gynaecol Obstet. 2023 Jul;162(1):317-324. doi: 10.1002/ijgo.14689. Epub 2023 Feb 7.
To evaluate the survival outcomes of appendectomy for a grossly normal appendix in patients with mucinous ovarian carcinomas.
Retrospective cohort study. Patients with mucinous ovarian carcinomas with grossly normal appendices who underwent primary surgery between 2002 and 2022 were enrolled. The overall survival (OS) and progression-free survival (PFS) of appendectomy and non-appendectomy groups were analyzed using the Kaplan-Meier method and compared using the log-rank test. Univariate and multivariate Cox regression analyses were used to determine the independent factors associated with OS and PFS.
Of 192 patients, appendectomy was performed in 138 (71.9%). Three (1.6%) patients had primary appendiceal tumors and two (1.0%) had appendiceal metastases of ovarian origin. The median follow-up time was 68.8 months. The OS and PFS were better in patients in the appendectomy group than in those in the non-appendectomy group (5-year OS: 80.72% vs. 65.05%, P = 0.012; 5-year PFS: 76.32% vs. 58.60%, P = 0.020). Independent factors associated with poor OS and PFS were no omentectomy, peritoneal seeding, and advanced International Federation of Gynecology and Obstetrics (FIGO) stage.
Appendectomy of a grossly normal appendix was not an independent prognostic factor for OS and PFS in patients with mucinous ovarian carcinomas.
评估在黏液性卵巢癌患者中，对大体正常的阑尾行切除术的生存结局。
回顾性队列研究。纳入了 2002 年至 2022 年间行初次手术且阑尾大体正常的黏液性卵巢癌患者。采用 Kaplan-Meier 法分析阑尾切除术组和非阑尾切除术组的总生存期（OS）和无进展生存期（PFS），并采用对数秩检验进行比较。采用单因素和多因素 Cox 回归分析确定与 OS 和 PFS 相关的独立因素。
在 192 例患者中，138 例行阑尾切除术（71.9%）。3 例（1.6%）患者存在原发性阑尾肿瘤，2 例（1.0%）患者存在卵巢来源的阑尾转移。中位随访时间为 68.8 个月。阑尾切除术组患者的 OS 和 PFS 优于非阑尾切除术组（5 年 OS：80.72% vs. 65.05%，P=0.012；5 年 PFS：76.32% vs. 58.60%，P=0.020）。与 OS 和 PFS 不良相关的独立因素包括无网膜切除术、腹膜播散和国际妇产科联盟（FIGO）晚期分期。
在黏液性卵巢癌患者中，大体正常的阑尾切除术不是 OS 和 PFS 的独立预后因素。
