利用产氧材料的潜力及其在器官特异性供氧中的应用。
Harnessing the potential of oxygen-generating materials and their utilization in organ-specific delivery of oxygen.
机构信息
Department of Chemical Engineering, University of Massachusetts, Lowell, Massachusetts 01854, USA.
Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
出版信息
Biomater Sci. 2023 Feb 28;11(5):1567-1588. doi: 10.1039/d2bm01329k.
The limited availability of transplantable organs hinders the success of patient treatment through organ transplantation. In addition, there are challenges with immune rejection and the risk of disease transmission when receiving organs from other individuals. Tissue engineering aims to overcome these challenges by generating functional three-dimensional (3D) tissue constructs. When developing tissues or organs of a particular shape, structure, and size as determined by the specific needs of the therapeutic intervention, a tissue specific oxygen supply to all parts of the tissue construct is an utmost requirement. Moreover, the lack of a functional vasculature in engineered tissues decreases cell survival upon implantation in the body. Oxygen-generating materials can alleviate this challenge in engineered tissue constructs by providing oxygen in a sustained and controlled manner. Oxygen-generating materials can be incorporated into 3D scaffolds allowing the cells to receive and utilize oxygen efficiently. In this review, we present an overview of the use of oxygen-generating materials in various tissue engineering applications in an organ specific manner as well as their potential use in the clinic.
可供移植的器官有限，这阻碍了通过器官移植来成功治疗患者。此外，在接受来自其他人的器官时，还存在免疫排斥和疾病传播的风险。组织工程旨在通过生成功能性的三维（3D）组织构建体来克服这些挑战。在开发具有特定形状、结构和尺寸的组织或器官时，根据治疗干预的具体需求，为组织构建体的所有部位提供特定的氧气供应是一个至关重要的要求。此外，工程化组织中缺乏功能性脉管系统会降低细胞在体内植入后的存活率。产氧材料可以通过持续和受控的方式提供氧气来缓解工程化组织构建体中的这一挑战。产氧材料可以被纳入 3D 支架中，使细胞能够高效地接收和利用氧气。在这篇综述中，我们介绍了产氧材料在各种器官特异性组织工程应用中的使用情况，以及它们在临床上的潜在用途。
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