Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 in Fenglin Road, Shanghai, 200032, China.
Institute of Nuclear Medicine, Fudan University, Shanghai, 200032, China.
Eur Radiol. 2023 Jul;33(7):5017-5027. doi: 10.1007/s00330-023-09389-3. Epub 2023 Jan 23.
Validation of [F]FDG PET/CT at ultralow-dose (0.37 MBq/kg) and compared to imaging at half-dose (1.85 MBq/kg).
This prospective head-to-head intraindividual study compared dynamic and static parameters of ultralow-dose with half-dose [F]FDG total-body PET/CT. In static imaging, the ultralow-dose groups of PET images were denoted ULD5, 60-65 min; ULD8, 60-68 min; ULD10, 60-70 min; and ULD15, 60-75 min. The half-dose group images were reconstructed to 60-61, 60-62, 60-63, and 60-75 min, defined as LD1, LD2, LD3, and LD15, respectively. A 5-point Likert scale was used to subjectively evaluate the quality of static PET images, with a score greater than 3 considered to meet the requirements for clinical diagnosis.
Thirty participants were included in this study, and in terms of kinetic indicators, no special differences were found between the two groups of normal organs and lesions. In static images, those in groups ULD8 and LD2 achieved scores of [Formula: see text] 3.0, meeting the requirements for clinical diagnosis. In static imaging, four lesions were missed in the LD1 group with a lesion detectability of 89.7% (35/39). In the meantime, lesions were not missed in the whole ultra-low dose group (ULD5, ULD8, ULD10, and ULD15) and half-dose groups (LD2 and LD3).
Compared with half-dose imaging, ultralow-dose [F]FDG total-body PET/CT imaging is clinically feasible, and there was no meaningful difference between the two groups of quantitative and qualitative analysis either dynamic or static images. Total-body PET/CT with ultralow-dose activity, the corresponding acquisition time of 8 min provides acceptable image quality and lesion detection.
ClinicalTrials.gov identifier: ChiCTR2000036487 KEY POINTS: • A prospective single-center study showed that the total-body PET scanner allows ultralow-dose [F]FDG imaging with acceptable image quality and lesion detectability. • For the participant, radiation exposure can be reduced with ultralow-dose [F]FDG total-body PET/CT imaging.
验证超低剂量（0.37MBq/kg）[F]FDG PET/CT 并与半剂量（1.85MBq/kg）进行比较。
这项前瞻性头对头个体研究比较了超低剂量和半剂量[F]FDG 全身 PET/CT 的动态和静态参数。在静态成像中，将超低剂量组的 PET 图像分别标记为 ULD5，60-65min；ULD8，60-68min；ULD10，60-70min；ULD15，60-75min。将半剂量组的图像重建为 60-61、60-62、60-63 和 60-75min，分别定义为 LD1、LD2、LD3 和 LD15。使用 5 分制主观评估静态 PET 图像的质量，评分大于 3 分被认为满足临床诊断要求。
本研究纳入 30 名参与者，在动力学指标方面，正常器官和病变两组之间没有发现特殊差异。在静态图像中，ULD8 和 LD2 组达到[公式：见文本]3.0 分，满足临床诊断要求。在静态成像中，LD1 组有 4 个病灶漏诊，病灶检出率为 89.7%（35/39）。同时，整个超低剂量组（ULD5、ULD8、ULD10 和 ULD15）和半剂量组（LD2 和 LD3）均未漏诊病灶。
与半剂量成像相比，超低剂量[F]FDG 全身 PET/CT 成像在临床上是可行的，无论是动态还是静态图像，两组之间的定量和定性分析也没有明显差异。全身 PET/CT 采用超低剂量活性，相应的采集时间为 8 分钟，可提供可接受的图像质量和病灶检出率。
ClinicalTrials.gov 标识符：ChiCTR2000036487
• 一项前瞻性单中心研究表明，全身 PET 扫描仪允许进行可接受的图像质量和病灶检出率的超低剂量[F]FDG 成像。
• 对于参与者而言，使用超低剂量[F]FDG 全身 PET/CT 成像可以降低辐射暴露。
