Jefferson J R, Hunt J B, Jamieson G A
American Red Cross Cell Biology Laboratory, Rockville, Maryland 20855.
J Med Chem. 1987 Nov;30(11):2013-6. doi: 10.1021/jm00394a015.
Adenosine 5'-diphosphate (ADP) and, uniquely, its C-2 derivatized analogues are able to induce platelet activation. We here report the synthesis of 2-[(3-aminopropyl)thio]-ADP from ADP itself via 1,N6-etheno-ADP. 2-[(3-Aminopropyl)thio]-ADP induced platelet aggregation with a potency about one-seventh that of ADP itself and should prove a useful intermediate in the synthesis of other probes of platelet function.
5'-二磷酸腺苷（ADP）及其独特的C-2衍生类似物能够诱导血小板活化。我们在此报告了通过1,N6-乙烯基-ADP从ADP本身合成2-[(3-氨基丙基)硫基]-ADP的方法。2-[(3-氨基丙基)硫基]-ADP诱导血小板聚集的效力约为ADP本身的七分之一，应被证明是合成其他血小板功能探针的有用中间体。
