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2-氨基-4-（肼基和羟氨基）-6-[(芳基)硫代]喹唑啉的合成及其抗疟和抗肿瘤作用

Synthesis and antimalarial and antitumor effects of 2-amino-4-(hydrazino and hydroxyamino)-6-[(aryl)thio]quinazolines.

作者信息

Werbel L M, Degnan M J

机构信息

Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105.

出版信息

J Med Chem. 1987 Nov;30(11):2151-4. doi: 10.1021/jm00394a038.

DOI:10.1021/jm00394a038

Abstract

A variety of analogues of 2,4-diamino-6-[(aryl)thio]quinazolines with known antimalarial properties were prepared wherein the 4-amino group was replaced by hydrazino and hydroxyamino moieties. Such changes were found to reduce markedly the antimalarial and antitumor properties of this series.

摘要

制备了多种具有已知抗疟特性的2,4-二氨基-6-[(芳基)硫代]喹唑啉类似物，其中4-氨基被肼基和羟氨基部分取代。发现这种变化显著降低了该系列的抗疟和抗肿瘤特性。

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Synthesis and antimalarial and antitumor effects of 2-amino-4-(hydrazino and hydroxyamino)-6-[(aryl)thio]quinazolines.2-氨基-4-（肼基和羟氨基）-6-[(芳基)硫代]喹唑啉的合成及其抗疟和抗肿瘤作用

J Med Chem. 1987 Nov;30(11):2151-4. doi: 10.1021/jm00394a038.

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