Li Xiaoling, Zhang Mudan, Zhou Gaoshi, Xie Zhuo, Wang Ying, Han Jing, Li Li, Wu Qirui, Zhang Shenghong
Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Cell Death Discov. 2023 Jan 23;9(1):24. doi: 10.1038/s41420-023-01329-w.
Rat sarcoma virus homolog (Rho) guanosine triphosphatases (GTPases) function as "molecular switch" in cellular signaling regulation processes and are associated with the pathogenesis of inflammatory bowel disease (IBD). This chronic intestinal tract inflammation primarily encompasses two diseases: Crohn's disease and ulcerative colitis. The pathogenesis of IBD is complex and considered to include four main factors and their interactions: genetics, intestinal microbiota, immune system, and environment. Recently, several novel pathogenic components have been identified. In addition, potential therapies for IBD targeting Rho GTPases have emerged and proven to be clinically effective. This review mainly focuses on Rho GTPases and their possible mechanisms in IBD pathogenesis. The therapeutic possibility of Rho GTPases is also discussed.
大鼠肉瘤病毒同源物（Rho）鸟苷三磷酸酶（GTP酶）在细胞信号调节过程中起“分子开关”的作用，并与炎症性肠病（IBD）的发病机制相关。这种慢性肠道炎症主要包括两种疾病：克罗恩病和溃疡性结肠炎。IBD的发病机制复杂，被认为包括四个主要因素及其相互作用：遗传学、肠道微生物群、免疫系统和环境。最近，已鉴定出几种新的致病成分。此外，针对Rho GTP酶的IBD潜在疗法已经出现，并已证明在临床上有效。本综述主要关注Rho GTP酶及其在IBD发病机制中的可能机制。还讨论了Rho GTP酶的治疗可能性。
