Rad52 单链退火蛋白超家族与同源重组的新认识
The Rad52 SSAP superfamily and new insight into homologous recombination.
机构信息
Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Tatzberg 47, 01307, Dresden, Germany.
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.
出版信息
Commun Biol. 2023 Jan 23;6(1):87. doi: 10.1038/s42003-023-04476-z.
Abstract
Rad52 is a highly conserved eukaryotic protein that can mediate the annealing of complementary DNA strands to initiate homologous recombination for the repair of double-strand breaks. Suspicions that at least some prokaryotic single-strand annealing proteins (SSAPs) are related to Rad52 have been discussed for more than two decades. Two recent cryo-EM structures now put the issue beyond doubt.
摘要
Rad52 是一种高度保守的真核蛋白，可介导互补 DNA 链的退火，启动同源重组以修复双链断裂。二十多年来，人们一直怀疑至少一些原核单链退火蛋白 (SSAP) 与 Rad52 有关。最近的两项冷冻电镜结构研究现在无疑证实了这一点。
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