俄罗斯人群中常见遗传变异与体重指数的关联。
Association of common genetic variants with body mass index in Russian population.
机构信息
Obninsk Institute for Nuclear Power Engineering, Obninsk, Russia.
Genotek Ltd., Moscow, Russia.
出版信息
Eur J Clin Nutr. 2023 May;77(5):574-578. doi: 10.1038/s41430-023-01265-z. Epub 2023 Jan 23.
BACKGROUND
Overweight is the scourge of modern society and a major risk factor for many diseases. For this reason, understanding the genetic component predisposing to high body mass index (BMI) seems to be an important task along with preventive measures aimed at improving eating behavior and increasing physical activity.
METHODS
We analyzed genetic data of a European cohort (n = 21,080, 47.25% women, East Slavs ancestry >80%) for 5 frequently found genes in the context of association with obesity: IPX3 (rs3751723), MC4R (rs17782313), TMEM18 (rs6548238), PPARG (rs1801282) and FTO (rs9939609).
RESULTS
Our study revealed significant associations of FTO (rs9939609) (β = 0.37 (kg/m)/allele, p = <2 × 10), MC4R (rs17782313) (β = 0.28 (kg/m)/allele, p = 5.79 × 10), TMEM18 (rs6548238) (β = 0.29 (kg/m)/allele, p = 2.43 × 10) with BMI and risk of obesity.
CONCLUSIONS
The results confirm the contribution of FTO, M4CR, and TMEM18 genes to the mechanism of body weight regulation and control.
背景
超重是现代社会的祸根，也是许多疾病的主要危险因素。出于这个原因，了解导致高体重指数（BMI）的遗传因素似乎是一项重要任务，同时还需要采取预防措施，旨在改善饮食行为和增加体育活动。
方法
我们分析了一个欧洲队列的遗传数据（n=21080，47.25%为女性，东斯拉夫人血统>80%），这些数据与肥胖相关的 5 个常见基因有关：IPX3（rs3751723）、MC4R（rs17782313）、TMEM18（rs6548238）、PPARG（rs1801282）和 FTO（rs9939609）。
结果
我们的研究揭示了 FTO（rs9939609）（β=0.37（kg/m）/等位基因，p=2×10）、MC4R（rs17782313）（β=0.28（kg/m）/等位基因，p=5.79×10）和 TMEM18（rs6548238）（β=0.29（kg/m）/等位基因，p=2.43×10）与 BMI 和肥胖风险之间存在显著关联。
结论
这些结果证实了 FTO、M4CR 和 TMEM18 基因对体重调节和控制机制的贡献。
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