Department of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan.
Department of Pharmacy, University of Agriculture, Faisalabad, Pakistan.
Clin Exp Pharmacol Physiol. 2021 Jul;48(7):954-965. doi: 10.1111/1440-1681.13498. Epub 2021 Apr 8.
Obesity has become a genuine global pandemic due to lifestyle and environmental modifications, and is associated with chronic lethal comorbidities. Various environmental factors such as lack of physical activity due to modernization and higher intake of energy-rich diets are primary obesogenic factors in pathogenesis of obesity. Genome-wide association study has identified the crucial role of FTO (fat mass and obesity) in human obesity. A bunch of SNPs in the first intron of FTO has been identified and subsequently correlated to body mass index and body composition. Findings of in silico, in vitro, and in vivo studies have manifested the robust role of FTO in regulation of energy expenditure and food consumption. Numerous studies have highlighted the mechanistic pathways behind the concomitant functions of FTO in adipogenesis and body size. Current investigation has also revealed the link of FTO neighbouring genes i.e., RPGRIP1L, IRX3 and IRX5 and epigenetic factors with obesity phenotypes. The motive behind this review is to cite the consequences of FTO on obesity vulnerability.
肥胖症由于生活方式和环境的改变已成为一种真正的全球流行疾病，并且与慢性致命合并症有关。由于现代化和高热量饮食摄入增加导致缺乏体力活动等各种环境因素是肥胖发病机制中的主要致肥胖因素。全基因组关联研究已经确定了 FTO（脂肪量和肥胖症）在人类肥胖中的关键作用。在 FTO 的第一个内含子中已经确定了一堆 SNP，并随后与体重指数和身体成分相关。体内、体外和体内研究的结果表明 FTO 在调节能量消耗和食物消耗方面的强大作用。大量研究强调了 FTO 在脂肪生成和体型方面的伴随功能的机制途径。目前的研究还揭示了 FTO 邻近基因即 RPGRIP1L、IRX3 和 IRX5 以及表观遗传因素与肥胖表型之间的联系。撰写本综述的目的是引用 FTO 对肥胖易感性的影响。
