Keeler R F, Stuart L D
United States Department of Agriculture, Poisonous Plant Research Laboratory, Logan, Utah 84321.
J Toxicol Clin Toxicol. 1987;25(4):273-86. doi: 10.3109/15563658708992631.
Groups of ewes were gavaged Veratrum californicum root-rhizome material over various 3 day periods during early gestation and their late-term fetuses examined. Resulting from gavage near day 29 were shortening of fetal metacarpal, metatarsal and tibial bones. Fibulae bowed severely when tibiae were shortened. Medial bowing of forelimbs at the fetlocks resulted from unequal shortening of fused metacarpi. Severe joint articular surface defects and arthrogryposis were present in some of the lambs from treatment ewes. There was bilateral and twinning symmetry in limb bone shortening. Severity of limb defects varied with gestational stage at time of gavage.
在妊娠早期的不同3天时间段内，给母羊灌喂加州藜芦根茎材料，并检查它们的晚期胎儿。在第29天左右灌喂导致胎儿掌骨、跖骨和胫骨缩短。当胫骨缩短时，腓骨严重弯曲。融合掌骨缩短不均导致前肢在跗关节处向内侧弯曲。处理过的母羊所产的一些羔羊出现严重的关节面缺陷和关节挛缩。四肢骨骼缩短存在双侧和双胎对称性。肢体缺陷的严重程度随灌喂时的妊娠阶段而变化。
