Department of Dermatology and Allergy, School of Medicine, Technical University of Munich, Munich, Germany
Department of Dermatology and Allergy, School of Medicine, Technical University of Munich, Munich, Germany.
BMJ Open. 2022 Sep 8;12(9):e059256. doi: 10.1136/bmjopen-2021-059256.
The pathogenesis of atopic diseases is highly complex, and the exact mechanisms leading to atopic dermatitis (AD) onset in infants remain mostly enigmatic. In addition to an interdependent network of components of skin development in young age and skin barrier dysfunction underlying AD development that is only partially understood, a complex interplay between environmental factors and lifestyle habits with skin barrier and immune dysregulation is suspected to contribute to AD onset. This study aims to comprehensively evaluate individual microbiome and immune responses in the context of environmental determinants related the risk of developing AD in the first 4 years of a child's life.
The 'Munich Atopic Prediction Study' is a comprehensive clinical and biological investigation of a prospective birth cohort from Munich, Germany. Information on pregnancy, child development, environmental factors, parental exposures to potential allergens and acute or chronic diseases of children and parents are collected by questionnaires together with a meticulous clinical examination by trained dermatologists focusing on allergies, skin health, and in particular signs of AD at 2 months after birth and then every 6 months. In addition, skin barrier functions are assessed through cutometry, corneometry and transepidermal water loss at every visit. These measurements are completed with allergy diagnostics and extensive microbiome analyses from stool and skin swabs as well as transcriptome analyses using skin microbiopsies.The aim is to assess the relevance of different known and yet unknown risk factors of AD onset and exacerbations in infants and to identify possible accessible and robust biomarkers.
The study is approved by the Ethical Committee of the Medical Faculty of the Technical University of Munich (reference 334/16S). All relevant study results will be presented at national and international conferences and in peer-reviewed journals.
特应性疾病的发病机制非常复杂，导致婴儿特应性皮炎（AD）发病的确切机制仍大多未解。除了年幼时皮肤发育成分的相互依存网络和AD 发展中部分理解的皮肤屏障功能障碍外，还怀疑环境因素和生活方式习惯与皮肤屏障和免疫失调的复杂相互作用导致 AD 发病。本研究旨在全面评估个体微生物组和免疫反应，同时考虑与儿童生命的头 4 年发生 AD 风险相关的环境决定因素。
“慕尼黑特应性预测研究”是对德国慕尼黑前瞻性出生队列的全面临床和生物学研究。通过问卷收集有关妊娠、儿童发育、环境因素、儿童和父母接触潜在过敏原以及急性或慢性疾病的信息，并由经过培训的皮肤科医生进行细致的临床检查，重点关注过敏、皮肤健康，特别是在出生后 2 个月和之后每 6 个月进行 AD 迹象。此外，通过皮肤电阻仪、皮肤角质层仪和经皮水分丢失测量仪评估皮肤屏障功能。这些测量与过敏诊断以及来自粪便和皮肤拭子的广泛微生物组分析以及使用皮肤微生物组学的转录组分析相结合。目的是评估不同已知和未知 AD 发病和加重的危险因素在婴儿中的相关性，并确定可能的可及和稳健的生物标志物。
该研究得到了慕尼黑技术大学医学院伦理委员会的批准（参考 334/16S）。所有相关研究结果将在国家和国际会议上以及同行评议期刊上发表。
