Gerner Trine, Halling Anne-Sofie, Rasmussen Rinnov Maria, Haarup Ravn Nina, Hjorslev Knudgaard Mette, Menné Bonefeld Charlotte, Ewertsen Caroline, Trautner Simon, Jakaša Ivone, Kezic Sanja, Skov Lone, Thyssen Jacob P
Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Copenhagen Research Group for Inflammatory Skin (CORGIS), Herlev and Gentofte Hospital, Hellerup, Denmark.
BMJ Open. 2020 Jul 12;10(7):e033801. doi: 10.1136/bmjopen-2019-033801.
Skin barrier development and dysfunction in premature and mature newborns is important for the risk of atopic dermatitis (AD).
The Barrier dysfunction in Atopic newBorns studY (BABY) Cohort is a prospective birth cohort study of 150 preterm children (gestational age (GA) below 37+0) and 300 term children (GA 37+0 to 41+6). Skin barrier is assessed through transepidermal water loss, tape stripping, Raman-spectroscopy and microbiome sampling. Clinical examinations are done and DNA from buccal swabs is collected for genetic analyses. Thymus size is assessed by ultrasound examination. Information on pregnancy, delivery, parental exposures and diseases are collected, and structured telephone interviews are conducted at 18 and 24 months to assess exogenous exposures in the child and onset of AD. Hanifin and Rajka criteria as well as The UK Working Party's Diagnostic Criteria for Atopic Dermatitis are used to diagnose AD. Severity of AD is assessed using the Eczema Area and Severity Index (EASI) and Patient Oriented Eczema Measure (POEM).
The study is approved by the scientific Ethical Committee of the Capital Region (H-16042289 and H-16042294).Outcomes will be presented at national and international conferences and in peer-reviewed publications.
早产和足月新生儿的皮肤屏障发育及功能障碍对于特应性皮炎（AD）的风险具有重要意义。
特应性新生儿皮肤屏障功能障碍研究（BABY）队列是一项前瞻性出生队列研究，纳入150名早产儿（胎龄（GA）低于37 + 0）和300名足月儿（GA 37 + 0至41 + 6）。通过经表皮水分流失、胶带剥离、拉曼光谱和微生物组采样来评估皮肤屏障。进行临床检查，并收集颊拭子的DNA用于基因分析。通过超声检查评估胸腺大小。收集有关妊娠、分娩、父母暴露和疾病的信息，并在18个月和24个月时进行结构化电话访谈，以评估儿童的外源性暴露和AD的发病情况。使用Hanifin和Rajka标准以及英国工作组的特应性皮炎诊断标准来诊断AD。使用湿疹面积和严重程度指数（EASI）和患者导向性湿疹评估（POEM）来评估AD的严重程度。
本研究已获得首都地区科学伦理委员会的批准（H - 16042289和H - 16042294）。研究结果将在国内和国际会议以及同行评审的出版物中发表。
