Kang Gideon G, Trevaskis Natalie L, Murphy Andrew J, Febbraio Mark A
Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Baker Heart & Diabetes Institute, Melbourne, VIC, Australia.
iScience. 2022 Dec 30;26(1):105905. doi: 10.1016/j.isci.2022.105905. eCollection 2023 Jan 20.
Sucrose, the primary circulating sugar in plants, contains equal amounts of fructose and glucose. The latter is the predominant circulating sugar in animals and thus the primary fuel source for various tissue and cell types in the body. Chronic excessive energy intake has, however, emerged as a major driver of obesity and associated pathologies including nonalcoholic fatty liver diseases (NAFLD) and the more severe nonalcoholic steatohepatitis (NASH). Consumption of a high-caloric, western-style diet induces gut dysbiosis and inflammation resulting in leaky gut. Translocation of gut-derived bacterial content promotes hepatic inflammation and ER stress, and when either or both of these are combined with steatosis, it can cause NASH. Here, we review the metabolic links between diet-induced changes in the gut and NASH. Furthermore, therapeutic interventions for the treatment of obesity and liver metabolic diseases are also discussed with a focus on restoring the gut-liver axis.
蔗糖是植物中主要的循环糖类，由等量的果糖和葡萄糖组成。后者是动物体内主要的循环糖类，因此是身体各种组织和细胞类型的主要燃料来源。然而，长期能量摄入过多已成为肥胖及相关疾病（包括非酒精性脂肪性肝病（NAFLD）和更严重的非酒精性脂肪性肝炎（NASH））的主要驱动因素。食用高热量的西式饮食会导致肠道菌群失调和炎症，进而引发肠漏。肠道来源的细菌成分易位会促进肝脏炎症和内质网应激，当这些情况中的任何一种或两者与脂肪变性相结合时，都可能导致NASH。在此，我们综述饮食诱导的肠道变化与NASH之间的代谢联系。此外，还讨论了肥胖和肝脏代谢疾病的治疗干预措施，重点是恢复肠-肝轴。
