Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
Eur J Endocrinol. 2022 Dec 1;187(6):K39-K45. doi: 10.1530/EJE-22-0508.
Due to its rarity, biochemical and histologic characteristics of androgen and glucocorticoid co-secreting adrenocortical adenomas are largely unknown. Herein, we report a case of adrenocortical adenoma that caused marked hyperandrogenemia and mild autonomous cortisol secretion. In this study, we investigated serum steroid profiles using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and histologic characteristics of the resected tumor. LC-MS/MS revealed highly elevated levels of 11-oxygenated androgens which have not been well studied in adrenal tumors. The expression patterns of steroidogenic enzymes determined by immunohistochemistry supported the results of steroid profiling and suggested the capacity of the tumor cells to produce 11-oxygenated androgens. Measurement of 11-oxygenated steroids should facilitate a better understanding of androgen-producing adrenocortical neoplasms.
由于其罕见性，雄激素和糖皮质激素共同分泌性肾上腺皮质腺瘤的生化和组织学特征在很大程度上尚不清楚。在此，我们报告了一例引起明显高雄激素血症和轻度自主皮质醇分泌的肾上腺皮质腺瘤。在这项研究中，我们使用液相色谱-串联质谱法（LC-MS/MS）研究了血清类固醇谱，并研究了切除肿瘤的组织学特征。LC-MS/MS 显示高度升高的 11-氧化雄激素水平，这些在肾上腺肿瘤中尚未得到很好的研究。免疫组织化学测定的类固醇生成酶表达模式支持类固醇谱的结果，并提示肿瘤细胞产生 11-氧化雄激素的能力。11-氧化类固醇的测量应有助于更好地了解产生雄激素的肾上腺皮质肿瘤。
