Department of Critical Care Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201620, China.
Department of Orthopaedics and Traumatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
ACS Appl Bio Mater. 2023 Feb 20;6(2):899-907. doi: 10.1021/acsabm.2c01089. Epub 2023 Jan 24.
Death from lethal hemorrhage remains a major problem in various emergency scenarios. There is a continuous interest in the development of absorbable hemostatic dressings that can control hemorrhage rapidly and can be left in the wound site without removal. In this study, we report a hemostatic gauze dressing based on -carboxyethyl chitosan (CECS) gelling fibers. The CECS fibrillar gauze combines ultra-hydrophilic, cationic chemical property of the fiber components with the fluffy nonwoven material form, exhibiting good conformability for wound filling, high fluid uptaking capacity, and enhanced blood-concentrating effect. In a swine femoral artery injury model, the CECS fibrillar gauze achieves shorter time to hemostasis and less blood loss compared with commercially available hemostatic dressings. This chitosan gelling fiber gauze demonstrates comparable bioabsorbability to clinically used absorbable hemostat and thus may be applied to treat fatal hemorrhage both in emergency medical services and in internal surgical procedures.
致命性出血仍是各种紧急情况下的主要问题。人们一直关注可快速止血且无需取出即可留在伤口部位的可吸收止血敷料的开发。在本研究中，我们报告了一种基于 -羧乙基壳聚糖 (CECS) 胶凝纤维的止血纱布敷料。CECS 纤维状纱布将纤维成分的超亲水性和阳离子化学性质与蓬松的无纺布材料形式相结合，具有良好的伤口填充顺应性、高流体吸收能力和增强的血液浓缩效果。在猪股动脉损伤模型中，与市售止血敷料相比，CECS 纤维状纱布达到止血的时间更短，失血量更少。这种壳聚糖胶凝纤维纱布的生物吸收能力与临床上使用的可吸收止血剂相当，因此可用于治疗紧急医疗服务和内部手术过程中的致命性出血。
