Takimoto M, Yano K, Fujita K, Yoshioka H, Sanae N, Maruyama S
Department of Pediatrics, National Sanatorium Dohoku Hospital.
Jpn J Antibiot. 1987 Jun;40(6):1125-8.
Twenty-one children, from 41 hours to 12 years of age, were given amikacin (AMK) for suspected bacterial infections. In the 41 hours old newborn infant, the half-life of AMK was 6.9 hours. As infants' ages increase, half-lives of AMK became shorter. The trend toward a shorter half-life in an older child was the most marked during neonatal period. At an age of 7 days, the half-life was shorter than 3 hours. In infants exceeding 6 months of age, ages did not make differences in the length of half-lives. The apparent volume of distribution in newborn was, as average, 350.6 ml/kg body weight. The average for children 5 years and older was smaller, 280.7 ml/kg. The peak level-dose ratio was 2.8 (micrograms X ml-1 X mg-1 X kg) in newborns. There was a tendency that this ratio increased with age. The average ratio for children over 5 years was 4.5 (micrograms X ml-1 X mg-1 X kg). In summary, the 2 remarkable observations obtained from the present study were; 1) The trend that the half-life of AMK shortens as the child grows older was clearest in neonatal period. 2) Peak serum level produced by the same dose per kilogram body weight had a tendency to increase with ages of children.
21名年龄从41小时至12岁的儿童因疑似细菌感染接受了阿米卡星（AMK）治疗。在41小时大的新生儿中，AMK的半衰期为6.9小时。随着婴儿年龄的增加，AMK的半衰期变短。在新生儿期，年龄较大儿童半衰期缩短的趋势最为明显。在7日龄时，半衰期短于3小时。在6个月以上的婴儿中，年龄对半衰期长度没有影响。新生儿的表观分布容积平均为350.6 ml/kg体重。5岁及以上儿童的平均值较小，为280.7 ml/kg。新生儿的峰浓度-剂量比为2.8（微克×ml-1×mg-1×kg）。该比值有随年龄增加的趋势。5岁以上儿童的平均比值为4.5（微克×ml-1×mg-1×kg）。总之，本研究得到的两个显著观察结果是：1）AMK半衰期随儿童年龄增长而缩短的趋势在新生儿期最为明显。2）每千克体重相同剂量产生的血清峰浓度有随儿童年龄增加的趋势。
