Horiuchi J, Takeda M, Nishio M, Mochizuki S, Morita K, Masaki N, Jingu K
Dept. of Radiology, Tokyo Medical & Dental Univ.
Gan No Rinsho. 1987 Aug;33(10):1177-83.
Cooperative study from six institutes was made for the late radiation damage of oral mucosa and mandibular bone. Analysis was made for the selected patients with oropharyngeal cancer for external beam alone and with tongue cancer for interstitial implant. All of them were followed at least two years without recurrence having no secondary treatment after initial radiotherapy. As for external beam alone, frequency of the mucosal ulcer was not increased with high dose level, but tolerance dose for the oral mucosa was limited from associated mandibular damage. Late damages were not likely after brachytherapy alone.
来自六个机构的合作研究针对口腔黏膜和下颌骨的晚期放射性损伤展开。对选定的仅接受外照射治疗的口咽癌患者以及接受组织间植入治疗的舌癌患者进行了分析。所有患者均随访至少两年，无复发，初始放疗后未接受二次治疗。对于仅接受外照射治疗的患者，高剂量水平时黏膜溃疡的发生率并未增加，但由于相关下颌骨损伤，口腔黏膜的耐受剂量受到限制。单纯近距离放疗后不太可能出现晚期损伤。
