基于虚拟现实的冥想干预对急性白血病患者诱导化疗期间焦虑和抑郁的影响：一项随机对照试验。
Effects of a Virtual Reality-Based Meditation Intervention on Anxiety and Depression Among Patients With Acute Leukemia During Induction Chemotherapy: A Randomized Controlled Trial.
作者信息
Zhang Bixia, Jin XiaoHuan, Kuang Xiaolin, Shen Biyu, Qiu Dingrong, Peng Jinrui, Chen Erhui, Dai Xiping, Chen Xiaoling, Wong Cho Lee
机构信息
Author Affiliations: The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong (Dr Jin and Dr Wong); The Second Clinical College of Guangzhou University of Chinese Medicine (Ms Zhang); Nursing Department, Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine (Ms Kuang); Nursing Department, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine (Ms Zhang and Dr Shen); Nursing Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine and Guangdong Provincial Hospital of Traditional Chinese Medicine (Ms Qiu); and Department of Hematology and Oncology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine and Guangdong Provincial Hospital of Traditional Chinese Medicine (Ms Peng, Ms X Chen, Dr Dai, and Mr E Chen), China.
出版信息
Cancer Nurs. 2023 Jan 23. doi: 10.1097/NCC.0000000000001206.
BACKGROUND
Emerging evidence supports that virtual reality (VR)-based meditation interventions may improve anxiety and depression among patients with cancer. However, empirical studies involving patients with acute leukemia during induction chemotherapy are limited.
OBJECTIVE
This study aimed to examine the effects of VR-based meditation intervention on alleviating anxiety and depression and improving the quality of life among patients with acute leukemia during induction chemotherapy.
METHODS
This randomized controlled trial recruited 63 patients newly diagnosed with acute leukemia. Participants were randomly assigned to an intervention group (received VR-based meditation for 20 min daily for 14 days) and a control group. Anxiety, depression, and quality of life were measured using the State Anxiety Inventory, the Center for Epidemiological Studies Depression Scale, and the Functional Assessment of Cancer Therapy-Leukemia Questionnaire, respectively. All outcomes were measured at baseline and post-intervention.
RESULTS
Compared with patients in the control group, those in the intervention group demonstrated a significantly greater reduction in anxiety (P = .04) and improvement in quality of life (P = .04). However, no significant difference was noted in depression levels between groups (P = .09), although a decreasing trend was observed in the intervention group.
CONCLUSION
Virtual reality-based meditation intervention effectively alleviated anxiety and improved the quality of life among acute leukemia patients during induction chemotherapy. Future randomized controlled trials with larger sample sizes and longer follow-up periods are warranted.
IMPLICATION FOR PRACTICE
Virtual reality-based meditation can be applied in clinical practice virtually anytime and anywhere to provide a convenient intervention for anxiety reduction for acute leukemia patients during induction chemotherapy.
背景
新出现的证据支持，基于虚拟现实（VR）的冥想干预可能改善癌症患者的焦虑和抑郁状况。然而，涉及急性白血病患者诱导化疗期间的实证研究有限。
目的
本研究旨在探讨基于VR的冥想干预对缓解急性白血病患者诱导化疗期间的焦虑和抑郁以及改善生活质量的效果。
方法
这项随机对照试验招募了63名新诊断为急性白血病的患者。参与者被随机分配到干预组（每天接受20分钟基于VR的冥想，共14天）和对照组。分别使用状态焦虑量表、流行病学研究中心抑郁量表和癌症治疗功能评估-白血病问卷来测量焦虑、抑郁和生活质量。所有结局指标在基线和干预后进行测量。
结果
与对照组患者相比，干预组患者的焦虑水平显著降低（P = .04），生活质量得到改善（P = .04）。然而，两组之间的抑郁水平没有显著差异（P = .09），尽管干预组有下降趋势。
结论
基于虚拟现实的冥想干预有效缓解了急性白血病患者诱导化疗期间的焦虑并改善了生活质量。未来有必要进行更大样本量和更长随访期的随机对照试验。
对实践的启示
基于虚拟现实的冥想几乎可以在临床实践中的任何时间和地点应用，为急性白血病患者诱导化疗期间减轻焦虑提供一种便捷的干预措施。
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