挑选一场（神经免疫）斗争，对抗成瘾的脆弱调节。
Picking a (neuroimmune) fight against fragile regulation of addiction.
机构信息
Center for Brain Immunology and Glia (BIG), Medical Scientist Training Program, Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA.
Center for Brain Immunology and Glia (BIG), Medical Scientist Training Program, Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA.
出版信息
Cell. 2023 Feb 2;186(3):464-466. doi: 10.1016/j.cell.2023.01.003. Epub 2023 Jan 23.
Abstract
T cells and their derived cytokines have been shown to modulate brain function. In this issue of Cell, Zhu, Yan, and colleagues demonstrate that opioid use impacts the crosstalk between the CNS and the peripheral immune system. Regulatory T cell (Treg)-derived IFN-γ signaling translates into synaptic weakening in the nucleus accumbens (NAc) to impart withdrawal-induced behavioral dysfunction.
摘要
T 细胞及其衍生的细胞因子已被证明可以调节大脑功能。在本期《细胞》杂志中，Zhu、Yan 和同事们表明，阿片类药物的使用会影响中枢神经系统和外周免疫系统之间的串扰。调节性 T 细胞（Treg）衍生的 IFN-γ信号转导导致伏隔核（NAc）中的突触减弱，从而导致戒断引起的行为功能障碍。
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