Department of Neurology, UTSA, San Antonio, TX, USA.
Department of Neurology, Loma Linda University, Loma Linda, CA, USA.
Amyotroph Lateral Scler Frontotemporal Degener. 2023 Aug;24(5-6):553-557. doi: 10.1080/21678421.2023.2171302. Epub 2023 Jan 24.
ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review astaxanthin which has plausible mechanisms for slowing ALS progression including antioxidant, anti-inflammatory, and anti-apoptotic effects. While there are no ALS-specific pre-clinical studies, one verified "ALS reversal" occurred in a person using a combination of alternative therapies which included astaxanthin. There have been no trials of astaxanthin in people living with ALS. Natural astaxanthin appears to be safe and inexpensive. Based on the above information, we support further pre-clinical and/or clinical trials of astaxanthin in disease models and PALS, respectively, to further elucidate efficacy.
ALSUntangled 审查了肌萎缩侧索硬化症 (PALS) 患者的替代和标签外治疗方法。在这里，我们回顾了虾青素，它具有减缓 ALS 进展的合理机制，包括抗氧化、抗炎和抗细胞凋亡作用。虽然没有专门针对 ALS 的临床前研究，但在使用包括虾青素在内的组合替代疗法的人中，有一个被证实的“ALS 逆转”案例。目前还没有虾青素在肌萎缩侧索硬化症患者中进行临床试验。天然虾青素似乎安全且价格低廉。基于上述信息，我们支持进一步在疾病模型和 PALS 中进行虾青素的临床前和/或临床试验，以进一步阐明其疗效。
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