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For the love of all that is holy, stop prescribing sodium valproate and carbamazepine together.看在上帝的份上，别再同时开丙戊酸钠和卡马西平了。
Pak J Med Sci. 2023 Jan-Feb;39(1):314. doi: 10.12669/pjms.39.1.7281.
2
A multicentre comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. Adult EPITEG Collaborative Group.丙戊酸钠与卡马西平治疗成人癫痫的多中心对照试验。成人癫痫协作研究组（EPITEG）
J Neurol Neurosurg Psychiatry. 1994 Jun;57(6):682-7. doi: 10.1136/jnnp.57.6.682.
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N Engl J Med. 1992 Sep 10;327(11):765-71. doi: 10.1056/NEJM199209103271104.
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Indapamide enhances the protective action of carbamazepine, phenobarbital, and valproate against maximal electroshock-induced seizures in mice.吲达帕胺增强卡马西平、苯巴比妥和丙戊酸钠对小鼠最大电休克诱导癫痫发作的保护作用。
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[Value of sodium valproate in the treatment of partial epilepsy].丙戊酸钠在部分性癫痫治疗中的价值
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Effect of carbamazepine and levetiracetam on coagulation parameters: Prothrombin time, activated partial thromboplastin time, D-dimer, and fibrinogen levels.卡马西平和左乙拉西坦对凝血参数的影响：凝血酶原时间、活化部分凝血活酶时间、D-二聚体及纤维蛋白原水平。
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The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond.抗癫痫药物的药理学和临床疗效：从溴化物盐到依诺巴比妥及其他。
CNS Drugs. 2021 Sep;35(9):935-963. doi: 10.1007/s40263-021-00827-8. Epub 2021 Jun 18.
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Pharmacokinetic characteristics of antiepileptic drugs (AEDs).抗癫痫药物（AEDs）的药代动力学特征。
Ment Health Clin. 2016 Mar 8;6(1):8-20. doi: 10.9740/mhc.2015.01.008. eCollection 2016 Jan.
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Mood stabilizer combinations: a review of safety and efficacy.
Am J Psychiatry. 1998 Jan;155(1):12-21. doi: 10.1176/ajp.155.1.12.
4
The mechanism of the carbamazepine-valproate interaction in humans.卡马西平与丙戊酸盐在人体内的相互作用机制。
Br J Clin Pharmacol. 1997 Jul;44(1):21-7. doi: 10.1046/j.1365-2125.1997.00607.x.
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Interaction between valproic acid and carbamazepine: an in vitro study of protein binding.
Ther Drug Monit. 1982;4(2):181-4. doi: 10.1097/00007691-198206000-00004.

看在上帝的份上，别再同时开丙戊酸钠和卡马西平了。

For the love of all that is holy, stop prescribing sodium valproate and carbamazepine together.

作者信息

Jawaid Wajid

出版信息

Pak J Med Sci. 2023 Jan-Feb;39(1):314. doi: 10.12669/pjms.39.1.7281.

DOI:10.12669/pjms.39.1.7281
PMID:36694773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9842997/
Abstract

Sodium valproate and carbamazepine are two time-tested drugs for treatment of epilepsy. Individually, they are usually excellent choices in treating a broad spectrum of epileptic seizures. They are, however, not friendly with each other. Their co-administration affects the drug levels of each other by influencing the action of hepatic enzymes. This write up attempts to give an overview of the mechanism of this drug interaction, and informs readers why this combination is a bad choice. The author hopes that this will help in raising awareness among the physicians regarding the dangers of this prescription, and in putting a full stop to this practice.

摘要

丙戊酸钠和卡马西平是两种久经考验的抗癫痫药物。单独使用时，它们通常是治疗多种癫痫发作的理想选择。然而，它们之间并不“友好”。同时使用会通过影响肝酶的活性来改变彼此的药物浓度。本文试图概述这种药物相互作用的机制，并告知读者为何这种联合用药并非明智之选。作者希望这将有助于提高医生对这种处方危险性的认识，并杜绝这种用药方式。