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可植入式心脏监测器在风险分层中的作用:现有适应证和临床证据。

Usefulness of insertable cardiac monitors for risk stratification: current indications and clinical evidence.

机构信息

Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

出版信息

Expert Rev Med Devices. 2023 Feb;20(2):85-97. doi: 10.1080/17434440.2023.2171862. Epub 2023 Jan 31.

Abstract

INTRODUCTION

The 2018 ESC Syncope guidelines expanded the indications for an insertable cardiac monitor (ICM) to patients with unexplained syncope and primary cardiomyopathy or inheritable arrhythmogenic disorders.

AREAS COVERED

This review article discusses the clinical evidence for using an ICM for risk stratification in different patient populations including Brugada syndrome, long QT syndrome, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, cardiac sarcoidosis, and congenital heart disease.

EXPERT OPINION

Clinical data on the usefulness of ICMs in different patient populations is limited but most studies demonstrate early detection of clinically relevant arrhythmias, such as nonsustained ventricular tachycardia or atrial fibrillation. It is important to emphasize that the study populations usually comprise selected populations where conventional diagnostic methods fail to clarify the mechanism of symptoms. The effect of an ICM on prognosis by earlier detection of arrhythmias is difficult to demonstrate in populations with rare disease. Risk stratification in patients with cardiomyopathy or inheritable arrhythmogenic disorders remains a niche indication for ICMs. The most important indication for an ICM remains unexplained syncope in patients at low risk of SCD. Given the device costs and uncertain clinical value of device-detected arrhythmias, it is unclear whether it is also useful in non-syncopal patients.

摘要

简介

2018 年 ESC 晕厥指南将不明原因晕厥和原发性心肌病或遗传性心律失常性疾病患者的适应证扩展到可植入式心脏监测器(ICM)。

涵盖领域

本文讨论了在不同患者人群中使用 ICM 进行风险分层的临床证据,包括 Brugada 综合征、长 QT 综合征、肥厚型心肌病、致心律失常性右心室心肌病、心脏结节病和先天性心脏病。

专家意见

关于 ICM 在不同患者人群中的有用性的临床数据有限,但大多数研究表明可早期检测到临床相关心律失常,如非持续性室性心动过速或心房颤动。重要的是要强调,研究人群通常包括传统诊断方法无法明确症状机制的选定人群。在罕见疾病患者中,通过早期检测心律失常来确定 ICM 对预后的影响是困难的。在心肌病或遗传性心律失常性疾病患者中的风险分层仍然是 ICM 的一个利基适应证。ICM 的最重要适应证仍然是低 SCD 风险的不明原因晕厥患者。鉴于设备成本和设备检测到的心律失常的不确定临床价值,在非晕厥患者中是否也有用尚不清楚。

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