Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Translational Immunology Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
APMIS. 2023 Apr;131(4):142-151. doi: 10.1111/apm.13298. Epub 2023 Feb 13.
Treatment of oral tongue squamous cell carcinoma (OTSCC) frequently includes surgery with postoperative radiotherapy (RT) or chemoradiotherapy (CRT). Resistance to RT or CRT remains a major clinical challenge and highlights the need to identify predictive markers for it. We included 71 OTSCC patients treated with surgery combined with RT or CRT. We evaluated the association between tumor budding, tumor-stroma ratio (TSR), depth of invasion (DOI), tumor-infiltrating lymphocytes (TILs), hypoxia-inducible factor-1alpha (HIF-1alpha) expression, octamer-binding transcription factor 4 (OCT4) expression, high-endothelial venules (HEVs), and disease-free survival (DFS) using uni- and multivariate analyses. No significant association was observed between the different histological and molecular markers (TSR, DOI, TILs, HEV, HIF-1alph, OCT4) and DFS. However, an associative trend between DOI, budding, and DFS was noted. Further studies with larger cohorts are needed to explore the prognostic value of DOI and budding for OTSCC patients treated with postoperative RT or CRT.
口腔舌鳞状细胞癌（OTSCC）的治疗常包括手术联合术后放疗（RT）或放化疗（CRT）。对 RT 或 CRT 的耐药性仍然是一个主要的临床挑战，这凸显了确定其预测标志物的必要性。我们纳入了 71 例接受手术联合 RT 或 CRT 治疗的 OTSCC 患者。我们使用单变量和多变量分析评估了肿瘤芽殖、肿瘤-基质比（TSR）、浸润深度（DOI）、肿瘤浸润淋巴细胞（TILs）、缺氧诱导因子-1alpha（HIF-1alpha）表达、八聚体结合转录因子 4（OCT4）表达、高内皮静脉（HEVs）与无病生存（DFS）之间的相关性。不同的组织学和分子标志物（TSR、DOI、TILs、HEV、HIF-1alpha、OCT4）与 DFS 之间无显著相关性。然而，DOI、芽殖与 DFS 之间存在关联趋势。需要进一步的大样本研究来探讨 DOI 和芽殖对接受术后 RT 或 CRT 治疗的 OTSCC 患者的预后价值。
