Department of Pediatrics, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, Shimotsuga, 321-0293, Japan.
Indian J Pediatr. 2023 May;90(5):510-512. doi: 10.1007/s12098-022-04462-z. Epub 2023 Jan 25.
A 17-d-old girl was diagnosed with disseminated herpes simplex virus-1 infection-associated hemophagocytic lymphohistiocytosis. The virus was detected in the neonate's blood and mandible. The neonate was treated with dexamethasone and acyclovir and discharged without neurological sequelae. The mother had no history of a herpes simplex virus-1 infection and did not have visible genital herpetic lesions; moreover, the neonate was delivered via an elective cesarean section. However, the day before the delivery, the mother had met with the neonate's grandmother, who had herpes labialis. Viral DNA was detected in bilateral breast milk samples; however, no superficial herpetic lesions were noted on both breasts. The authors speculated that the neonate may have acquired the infection via contaminated breast milk. Thus far, only one neonatal case of this infection contracted via breast milk has been reported. Further studies on breast milk as a transmission route for these infections are required.
一名 17 日龄女婴被诊断为播散性单纯疱疹病毒 1 感染相关性噬血细胞性淋巴组织细胞增生症。病毒在新生儿的血液和下颌骨中被检出。新生儿接受地塞米松和阿昔洛韦治疗后出院，无神经后遗症。患儿母亲无单纯疱疹病毒 1 感染史，无明显生殖器疱疹皮损；此外，新生儿系择期剖宫产娩出。然而，在分娩前一天，母亲曾与患儿的祖母会面，而祖母患有唇疱疹。双侧母乳样本中均检测到病毒 DNA；但双侧乳房均未见明显疱疹皮损。作者推测新生儿可能通过受污染的母乳感染了该病毒。迄今为止，仅报道过一例通过母乳感染该病毒的新生儿病例。需要进一步研究母乳作为这些感染传播途径的可能性。
