Department of Nursing, Al-Maarif University College, Ramadi, Iraq.
Department of Biology, College of Science, Wasit University, Al-Kut, Iraq.
Cell Stress Chaperones. 2023 Mar;28(2):145-150. doi: 10.1007/s12192-023-01323-2. Epub 2023 Jan 25.
Endometriosis is a chronic gynecologic disorder characterized by abnormal growth of endometrium-like tissues in the ectopic regions of the pelvic peritoneum. The pathophysiology of endometriosis is not completely understood; however, excessive endometrial cell proliferation together with resistance to apoptosis facilitates the migration, implantation, and survival of endometrial cells in the distant sites. Endoplasmic reticulum (ER) stress response (also called unfolded protein response) is a cellular defense mechanism triggered by ER stress. When severe enough, the so-called response initiates cell suicide, i.e., apoptosis. Therefore, therapeutic induction of ER stress in endometriotic cells could promote apoptosis and contribute to the management of disease. In this review, we discuss the pathogenic role of ER stress in endometriosis and the most recent findings regarding the induction of ER stress in connection with endometriosis.
子宫内膜异位症是一种慢性妇科疾病，其特征是子宫内膜样组织在盆腔腹膜的异位区域异常生长。子宫内膜异位症的病理生理学尚未完全阐明；然而，子宫内膜细胞过度增殖以及对细胞凋亡的抵抗促进了子宫内膜细胞在远处部位的迁移、植入和存活。内质网（ER）应激反应（也称为未折叠蛋白反应）是由 ER 应激触发的细胞防御机制。当应激足够严重时，所谓的反应会引发细胞自杀，即细胞凋亡。因此，在内异症细胞中诱导 ER 应激可以促进细胞凋亡，有助于疾病的治疗。在这篇综述中，我们讨论了 ER 应激在子宫内膜异位症中的致病作用，以及与子宫内膜异位症相关的 ER 应激诱导的最新发现。
