Samokhvalova Svetlana, Lutz Jean-François
Université de Strasbourg, CNRS, ISIS, 8 allée Gaspard Monge, 67000, Strasbourg, France.
Angew Chem Int Ed Engl. 2023 Apr 11;62(16):e202300014. doi: 10.1002/anie.202300014. Epub 2023 Feb 14.
Macromolecular information transfer can be defined as the process by which a coded monomer sequence is communicated from one macromolecule to another. In such a transfer process, the information sequence can be kept identical, transformed into a complementary sequence or even translated into a different molecular language. Such mechanisms are crucial in biology and take place in DNA→DNA replication, DNA→RNA transcription and RNA→protein translation. In fact, there would be no life on Earth without macromolecular information transfer. Mimicking such processes with synthetic macromolecules would also be of major scientific relevance because it would open up new avenues for technological applications (e.g. data storage and processing) but also for the creation of artificial life. In this important context, this minireview summarizes recent research about information transfer in synthetic oligomers and polymers. Medium- and long-term perspectives are also discussed.
大分子信息传递可定义为将编码的单体序列从一个大分子传递到另一个大分子的过程。在这样的传递过程中，信息序列可以保持不变，转化为互补序列，甚至翻译成不同的分子语言。这些机制在生物学中至关重要，发生在DNA→DNA复制、DNA→RNA转录和RNA→蛋白质翻译过程中。事实上，没有大分子信息传递，地球上就不会有生命。用合成大分子模拟这些过程也具有重大的科学意义，因为这将为技术应用（如数据存储和处理）以及创造人工生命开辟新途径。在这一重要背景下，本综述总结了关于合成低聚物和聚合物中信息传递的最新研究。还讨论了中长期展望。
