From the Radiation Biology Research Center, Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Menopause. 2023 Feb 1;30(2):201-207. doi: 10.1097/GME.0000000000002117. Epub 2022 Dec 13.
Cornus mas fruit has various antioxidants and anti-inflammatory properties, so this study aims at assessing its effect on menopausal symptoms and sex hormones in postmenopausal women.
In the current randomized, double-blind clinical trial, 84 individuals (42 per group) were participated. C mas hydroalcoholic extract was prepared, and participants received 300 mg C mas extract or placebo three times a day (900 g in total) for 8 weeks. The demographic, dietary intake, and physical activity information were gathered. Anthropometric indices were measured by standard methods. Furthermore, menopause symptoms were assessed by Greene Climacteric Scale. Also, sex hormones were measured by enzyme-linked immunosorbent assay.
Based on the results, there was a significant difference in total Greene score reduction between the intervention and placebo groups (-3.19 ± 0.54, -0.76 ± 0.32, and P < 0.001). In addition, vasomotor symptoms had a remarkable decrease in the C mas extract group (P < 0.001). Also, the intervention group demonstrated a decreasing trend in the number and duration of hot flushes. Moreover, follicle-stimulating hormone remarkably decreased and estradiol increased in the intervention group (P = 0.016 and P = 0.018).
It has been found that the extract of C mas fruit has a favorable effect on vasomotor symptoms, sex hormones, and related complications in women experiencing menopausal symptoms.
山茱萸果实具有多种抗氧化和抗炎特性，因此本研究旨在评估其对绝经后妇女更年期症状和性激素的影响。
在当前这项随机、双盲临床试验中，共有 84 名参与者（每组 42 名）入组。制备山茱萸水醇提取物，参与者每天服用 300mg 的 C 马提取物或安慰剂三次（共 900g），持续 8 周。收集人口统计学、饮食摄入和身体活动信息。采用标准方法测量人体测量学指数。此外，使用格林绝经评分量表评估更年期症状。还通过酶联免疫吸附试验测量性激素。
根据结果，干预组和安慰剂组的总格林评分降低有显著差异（-3.19 ± 0.54、-0.76 ± 0.32，P < 0.001）。此外，山茱萸提取物组的血管舒缩症状显著减少（P < 0.001）。此外，干预组的热潮次数和持续时间呈下降趋势。此外，干预组的卵泡刺激素显著降低，雌二醇增加（P = 0.016 和 P = 0.018）。
研究发现，山茱萸果实提取物对有更年期症状的妇女的血管舒缩症状、性激素及其相关并发症有良好的作用。
