来自马钱子根皮的一种叔生物碱的化学与药理学

Chemistry and pharmacology of a tertiary alkaloid from Strychnos trinervis root bark.

作者信息

Melo M F, Santos C A, Chiappeta A A, de Mello J F, Mukherjee R

机构信息

Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, Brazil.

出版信息

J Ethnopharmacol. 1987 May;19(3):319-25. doi: 10.1016/0378-8741(87)90007-9.

DOI:10.1016/0378-8741(87)90007-9

PMID:3669691

Abstract

Bisnordihydrotoxiferine has been isolated as the major alkaloid from the root bark of Strychnos trinervis. This compound shows a wide antimicrobial spectrum against gram-positive, gram-negative and acid-fast microorganisms, filamentous and yeast-like fungi and also phytopathogenic microorganisms. Preliminary studies also reveal some cytotoxic activity in KB cells which was confirmed by tests against sarcoma 180 tumors.

摘要

双去甲二氢毒箭树碱已从马钱子的根皮中分离出来，作为主要生物碱。该化合物对革兰氏阳性菌、革兰氏阴性菌、抗酸菌、丝状真菌和酵母样真菌以及植物病原微生物均有广泛的抗菌谱。初步研究还揭示了其在KB细胞中的一些细胞毒性活性，这一点通过对肉瘤180肿瘤的测试得到了证实。