从交互木、戴尔马钱子和杜英马钱子中分离得到的一些新的交叉型生物碱。

Some new decussine-type alkaloids from Strychnos decussata, Strychnos dale and Strychnos elaecocarpa.

作者信息

Rolfsen W N, Olaniyi A A, Verpoorte R, Bohlin L

出版信息

J Nat Prod. 1981 Jul-Aug;44(4):415-21. doi: 10.1021/np50016a004.

Abstract

From the stem bark of Strychnos decussata (Pappe) Gilg (Loganiaceae), four tertiary indole alkaloids have been isolated: bisnordihydrotoxiferine and three new alkaloids. The structures of two of the new alkaloids, 3,14-dihydrodecussine (III) and 10-hydroxy-3,14-dihydrodecussine (IV), have been ascribed on the basis of their spectral data. The muscle-relaxant activity of these new compounds is discussed. Further studies of the alkaloids present in the stem bark of Strychnos dale and Strychnos elaeocarpa revealed the presence of decussine (V) and dihydrodecussine in S. dale and decussine, dihydrodecussine, and bisnordihydrotoxiferine in S. elaeocarpa.

摘要

从毒鼠子（马钱科）的茎皮中，已分离出四种叔吲哚生物碱：双去甲二氢毒鼠碱和三种新生物碱。基于光谱数据，已确定了两种新生物碱3,14 - 二氢毒鼠碱（III）和10 - 羟基 - 3,14 - 二氢毒鼠碱（IV）的结构。讨论了这些新化合物的肌肉松弛活性。对毒鼠李和光叶毒鼠子茎皮中生物碱的进一步研究表明，毒鼠李中存在毒鼠碱（V）和二氢毒鼠碱，光叶毒鼠子中存在毒鼠碱、二氢毒鼠碱和双去甲二氢毒鼠碱。