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通过低频刺激脚桥核改善帕金森病模型中的日间过度嗜睡。

Excessive daytime sleepiness in a model of Parkinson's disease improved by low-frequency stimulation of the pedunculopontine nucleus.

作者信息

Davin Aurélie, Chabardès Stéphan, Devergnas Annaelle, Benstaali Caroline, Gutekunst Claire-Anne N, David Olivier, Torres-Martinez Napoléon, Piallat Brigitte

机构信息

Univ. Grenoble Alpes, CEA, LETI, Clinatec, 38000, Grenoble, France.

Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000, Grenoble, France.

出版信息

NPJ Parkinsons Dis. 2023 Jan 25;9(1):9. doi: 10.1038/s41531-023-00455-7.

Abstract

Patients with Parkinson's disease often complain of excessive daytime sleepiness which negatively impacts their quality of life. The pedunculopontine nucleus, proposed as a target for deep brain stimulation to improve freezing of gait in Parkinson's disease, is also known to play a key role in the arousal system. Thus, the putative control of excessive daytime sleepiness by pedunculopontine nucleus area stimulation merits exploration for treating Parkinson's disease patients. To this end, two adult nonhuman primates (macaca fascicularis) received a deep brain stimulation electrode implanted into the pedunculopontine nucleus area along with a polysomnographic equipment. Stimulation at low frequencies and high frequencies was studied, in healthy and then MPTP-treated nonhuman primates. Here, we observed that MPTP-treated nonhuman primates suffered from excessive daytime sleepiness and that low-frequency stimulation of the pedunculopontine nucleus area was effective in reducing daytime sleepiness. Indeed, low-frequency stimulation of the pedunculopontine nucleus area induced a significant increase in sleep onset latency, longer continuous periods of wakefulness and thus, a partially restored daytime wake architecture. These findings may contribute to the development of new therapeutic strategies in patients suffering from excessive daytime sleepiness.

摘要

帕金森病患者经常抱怨白天过度嗜睡,这对他们的生活质量产生负面影响。脚桥核被提议作为深部脑刺激的靶点,以改善帕金森病患者的步态冻结,同时也已知其在觉醒系统中起关键作用。因此,通过刺激脚桥核区域来控制白天过度嗜睡的可能性值得探索,以治疗帕金森病患者。为此,两只成年非人灵长类动物(食蟹猴)接受了深部脑刺激电极植入脚桥核区域,并配备了多导睡眠图设备。在健康的以及随后用MPTP处理的非人灵长类动物中,研究了低频和高频刺激。在此,我们观察到用MPTP处理的非人灵长类动物患有白天过度嗜睡,并且脚桥核区域的低频刺激有效地减少了白天嗜睡。实际上,脚桥核区域的低频刺激导致睡眠开始潜伏期显著增加,清醒的连续时间更长,从而部分恢复了白天的觉醒结构。这些发现可能有助于为患有白天过度嗜睡的患者开发新的治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26ed/9876933/392f278b4efe/41531_2023_455_Fig1_HTML.jpg

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