Koumarianou Greta, Wang Irene, Satterthwaite Lincoln, Patterson David
Physics Department, University of California, Santa Barbara, Santa Barbara, CA, USA.
Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, USA.
Commun Chem. 2022 Mar 14;5(1):31. doi: 10.1038/s42004-022-00641-3.
Straightforward identification of chiral molecules in multi-component mixtures of unknown composition is extremely challenging. Current spectrometric and chromatographic methods cannot unambiguously identify components while the state of the art spectroscopic methods are limited by the difficult and time-consuming task of spectral assignment. Here, we introduce a highly sensitive generalized version of microwave three-wave mixing that uses broad-spectrum fields to detect chiral molecules in enantiomeric excess without any prior chemical knowledge of the sample. This method does not require spectral assignment as a necessary step to extract information out of a spectrum. We demonstrate our method by recording three-wave mixing spectra of multi-component samples that provide direct evidence of enantiomeric excess. Our method opens up new capabilities in ultrasensitive phase-coherent spectroscopic detection that can be applied for chiral detection in real-life mixtures, raw products of chemical reactions and difficult to assign novel exotic species.
在成分未知的多组分混合物中直接识别手性分子极具挑战性。当前的光谱和色谱方法无法明确识别各组分，而最先进的光谱方法则受限于光谱归属这一困难且耗时的任务。在此，我们引入了一种高灵敏度的广义微波三波混频方法，该方法利用广谱场来检测对映体过量的手性分子，而无需对样品有任何先验化学知识。此方法无需将光谱归属作为从光谱中提取信息的必要步骤。我们通过记录多组分样品的三波混频光谱来演示我们的方法，这些光谱提供了对映体过量的直接证据。我们的方法开启了超灵敏相位相干光谱检测的新能力，可应用于实际混合物、化学反应的原始产物以及难以归属的新型奇特物种的手性检测。
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