Satterthwaite Lincoln, Pérez Cristóbal, Steber Amanda L, Finestone Dylan, Broadrup Robert L, Patterson David
Department of Chemistry , Haverford College , Haverford , Pennsylvania 19041 , United States.
Deutsches Elektronen-Synchrotron DESY , Notkestraβe 85 , D-22607 Hamburg , Germany.
J Phys Chem A. 2019 Apr 11;123(14):3194-3198. doi: 10.1021/acs.jpca.9b02115. Epub 2019 Mar 27.
Many achiral molecules can be made chiral by appropriate positioning of an isotope. Accurate detection of this type of chirality has remained elusive, and there is as yet no general method for detection of isotopically chiral species. Here, we present the first application of microwave three-wave mixing to isotopically chiral molecules, detecting enantiomeric excess in ( R/ S)-benzyl-α-D alcohol. Our method is expected to be applicable to a broad range of isotopically chiral molecules with a prochiral parent species.
许多非手性分子可通过同位素的适当定位而变为手性分子。对这类手性的准确检测一直难以实现，目前尚无检测同位素手性物种的通用方法。在此，我们展示了微波三波混频在同位素手性分子中的首次应用，检测了（R/S）-苄基-α-D醇中的对映体过量。我们的方法有望适用于具有前手性母体物种的广泛同位素手性分子。
