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关于与纳米团簇相互作用的蛋白质的开放性问题。

Open questions on proteins interacting with nanoclusters.

作者信息

Antoine Rodolphe, Maysinger Dusica, Sancey Lucie, Bonačić-Koutecký Vlasta

机构信息

Institut Lumière Matière UMR 5306, Université Claude Bernard Lyon 1, CNRS, Univ Lyon, F- 69100, Villeurbanne, France.

Department of Pharmacology & Therapeutics, McGill University, Montréal, QC, H3G 1Y6, Canada.

出版信息

Commun Chem. 2022 Apr 6;5(1):47. doi: 10.1038/s42004-022-00665-9.

DOI:10.1038/s42004-022-00665-9
PMID:36697869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9814327/
Abstract

Interfacing ultrasmall metal nanoclusters (NCs) with proteins can present a dual opportunity: proteins can be used for protecting NCs, and the surface ligands of NCs may interact with proteins. Here, the authors identify and discuss remaining open questions surrounding the bio-NC interface that call for future research efforts.

摘要

将超小型金属纳米团簇(NCs)与蛋白质结合可带来双重机遇:蛋白质可用于保护纳米团簇,且纳米团簇的表面配体可能与蛋白质相互作用。在此,作者识别并讨论了围绕生物纳米团簇界面仍未解决的开放性问题,这些问题需要未来的研究努力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8301/9814327/b71a022ad3a5/42004_2022_665_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8301/9814327/e956282f3cc1/42004_2022_665_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8301/9814327/b71a022ad3a5/42004_2022_665_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8301/9814327/e956282f3cc1/42004_2022_665_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8301/9814327/b71a022ad3a5/42004_2022_665_Fig2_HTML.jpg

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Chemistry. 2022 Jul 11;28(39):e202200570. doi: 10.1002/chem.202200570. Epub 2022 Jun 15.
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Insights into the Impact of Gold Nanoclusters AuSG on Human Microglia.
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