Cancer Targets & Experimental Therapeutics, Institute for Advanced Biosciences (IAB), University of Grenoble Alpes- INSERM U1209 - CNRS UMR 5309, Grenoble, France; Grenoble Alpes University Hospital, Grenoble, France.
Cancer Targets & Experimental Therapeutics, Institute for Advanced Biosciences (IAB), University of Grenoble Alpes- INSERM U1209 - CNRS UMR 5309, Grenoble, France.
Nanomedicine. 2019 Aug;20:102011. doi: 10.1016/j.nano.2019.04.014. Epub 2019 May 17.
With the objective to evaluate the potential of ultra-small gold (Au) nanoclusters (NCs) for optical image-guided surgery, we synthesized and characterized AuNCs shelled by zwitterionic or pegylated ligands. The toxicity of the different AuNCs was evaluated on the Head and Neck Squamous Cell Carcinoma (HNSCC) CAL-33 and SQ20B cell lines in vitro. The safer AuNCs were administrated intravenously to mice for the determination of the pharmacokinetic properties. Biodistributions were performed on orthotopic CAL-33 HNSCC-bearing mice. Finally, the AuNCs were used for image-guided surgery, allowing the increase of the survival time vs. control animals, and the number of animals without any local recurrence.
为了评估超小金（Au）纳米团簇（NCs）在光学图像引导手术中的潜力，我们合成并表征了由两性离子或聚乙二醇化配体包裹的 AuNCs。不同 AuNCs 的体外毒性在头颈部鳞状细胞癌（HNSCC）CAL-33 和 SQ20B 细胞系上进行了评估。更安全的 AuNCs 被静脉注射到小鼠体内，以确定其药代动力学特性。在原位 CAL-33 HNSCC 荷瘤小鼠中进行了生物分布研究。最后，AuNCs 用于图像引导手术，使动物的存活时间相对于对照组增加，且没有局部复发的动物数量增加。
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