MS-RIDD为基于质谱的脂质组学中双键的常规定位铺平了道路。
MS-RIDD paves the way toward routine double bond localization in mass spectrometry-based lipidomics.
作者信息
Lamp Leonida Marion, Hartler Jürgen
机构信息
Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria.
Field of Excellence BioHealth, University of Graz, Graz, Austria.
出版信息
Commun Chem. 2022 Dec 29;5(1):181. doi: 10.1038/s42004-022-00805-1.
Abstract
Pinpointing double bond (C=C) positions in native lipid extracts is beyond the capabilities of standard mass spectrometry-based approaches. This article highlights a novel untargeted workflow supported by the open-source software MS-RIDD, that allows for semi-automated annotation of C=C locations with high confidence.
摘要
确定天然脂质提取物中碳碳双键（C=C）的位置超出了基于标准质谱方法的能力范围。本文重点介绍了一种由开源软件MS-RIDD支持的新型非靶向工作流程，该流程能够以高可信度对碳碳双键位置进行半自动注释。
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