Department of Clinical Medicine, Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
Center for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Int J Obes (Lond). 2023 Mar;47(3):207-214. doi: 10.1038/s41366-023-01259-8. Epub 2023 Jan 25.
OBJECTIVE: Adult overweight is associated with increased risk of diverticular disease (DD). We investigated associations between birthweight and childhood body mass index (BMI) and DD. METHODS: Cohort study of 346,586 persons born during 1930-1996 with records in the Copenhagen School Health Records Register. Data included birthweight, and height and weight from ages 7 through 13. We used Cox proportional hazard regression to examine associations between birthweight and BMI z-scores and DD registered in the Danish National Patient Registry. Due to non-proportionality, we followed participants from age 18-49 and from age 50. RESULTS: During follow-up, 5459 (3.2%) women and 4429 (2.5%) men had DD. For low and high BMI in childhood, we observed a higher risk of DD before age 50. Among women with z-scores <0 at age 13, the hazard ratio (HR) was 1.16 [95% confidence interval (CI): 0.98-1.39] per one-point lower z-score. For z-scores ≥0 at age 13, the HR was 1.30 (95% CI: 1.11-1.51) per one-point higher z-score. Among men with z-scores <0 at age 13, the HR was 1.02 (95% CI: 0.85-1.22). For z-scores ≥0 at age 13, the HR was 1.54 (95% CI: 1.34-1.78). Z-scores ≥0 were not associated with DD after age 50. Among women only, birthweight was inversely associated with DD before age 50 [HR = 0.90 (95% CI: 0.83-0.99) per 500 g higher birthweight]. CONCLUSION: BMI z-scores below and above zero in childhood were associated with higher risk of DD before age 50. In addition, we observed lower risk of DD among women, the higher their birthweight.
目的：成人超重与憩室病（DD）风险增加有关。我们研究了出生体重和儿童时期体重指数（BMI）与 DD 之间的关系。
方法：对 1930 年至 1996 年期间出生的 346586 人进行队列研究，这些人在哥本哈根学校健康记录登记处有记录。数据包括出生体重以及 7 至 13 岁时的身高和体重。我们使用 Cox 比例风险回归来检查出生体重和 BMI z 分数与丹麦国家患者登记处登记的 DD 之间的关系。由于不成比例，我们从 18-49 岁和 50 岁开始随访参与者。
结果：在随访期间，5459 名女性（3.2%）和 4429 名男性（2.5%）患有 DD。对于儿童时期低和高 BMI，我们观察到 50 岁之前 DD 的风险更高。在 13 岁时 z 分数<0 的女性中，每降低一个 z 分数，危险比（HR）为 1.16（95%置信区间[CI]：0.98-1.39）。对于 13 岁时 z 分数≥0 的女性，每增加一个 z 分数，HR 为 1.30（95% CI：1.11-1.51）。在 13 岁时 z 分数<0 的男性中，HR 为 1.02（95% CI：0.85-1.22）。对于 13 岁时 z 分数≥0 的男性，HR 为 1.54（95% CI：1.34-1.78）。在 50 岁之后，z 分数≥0 与 DD 无关。仅在女性中，在 50 岁之前，出生体重每增加 500 克，与 DD 的风险呈反比[HR=0.90（95% CI：0.83-0.99）]。
结论：儿童时期 z 分数低于和高于零与 50 岁之前 DD 风险增加有关。此外，我们观察到出生体重较高的女性 DD 风险较低。
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