Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.
Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense C, Denmark.
Eur J Epidemiol. 2020 Mar;35(3):251-258. doi: 10.1007/s10654-020-00605-8. Epub 2020 Jan 28.
Adult obesity increases risks of renal cell carcinoma (RCC). This study investigated if birth weight, child body mass index (BMI) and height are associated with adult RCC. The study included 301,418 children (152,569 boys) from the Copenhagen School Health Records Register born 1930-1985 with measured weights and heights at ages 7 to 13 years. Birth weight was obtained by parental report. BMI and height were transformed to z-scores, and BMI was categorized as normal BMI or overweight. RCC was identified by linkage to the Danish Cancer Registry. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox proportional hazards regression. During follow-up, 1010 individuals (680 men) were diagnosed with RCC. BMI and height were positively associated with RCC with no significant sex-differences (age 13: HR = 1.14, 95% CI 1.06-1.23 per BMI z-score, HR = 1.12, 95% CI 1.05-1.20 per height z-score). Compared to children with normal BMI at ages 7 and 13 years, children with overweight only at age 13 had higher risks of RCC (HR = 1.67, 95% CI 1.24-2.26). Compared to children with average growth in height, persistently taller-than-average children (HR = 1.06, 95% CI 1.03-1.10) and children who changed from average to above-average height (HR = 1.08, 95% CI 1.01-1.15) had increased risks of RCC. Birth weight was positively associated with RCC (HR = 1.12, 95% CI 1.05-1.20 per 500 grams). Birth weight, childhood BMI and height were positively associated with RCC risk in men and women.
成人肥胖会增加肾细胞癌（RCC）的风险。本研究调查了出生体重、儿童体重指数（BMI）和身高是否与成人 RCC 相关。该研究纳入了 301418 名（男 152569 名）儿童，他们出生于 1930 年至 1985 年，在 7 至 13 岁时测量了体重和身高。出生体重通过父母报告获得。BMI 和身高转换为 z 分数，BMI 分为正常 BMI 或超重。通过与丹麦癌症登记处的链接确定 RCC 病例。使用 Cox 比例风险回归估计危险比（HR）和 95%置信区间（CI）。随访期间，有 1010 人（680 名男性）被诊断患有 RCC。BMI 和身高与 RCC 呈正相关，且无显著的性别差异（13 岁时：每 BMI z 分数增加 1 个单位，HR 为 1.14，95%CI 为 1.06-1.23；每身高 z 分数增加 1 个单位，HR 为 1.12，95%CI 为 1.05-1.20）。与 7 岁和 13 岁时 BMI 正常的儿童相比，仅 13 岁时超重的儿童患 RCC 的风险更高（HR 为 1.67，95%CI 为 1.24-2.26）。与身高增长平均的儿童相比，持续高于平均身高的儿童（HR 为 1.06，95%CI 为 1.03-1.10）和身高从平均增长到高于平均的儿童（HR 为 1.08，95%CI 为 1.01-1.15）患 RCC 的风险增加。出生体重与 RCC 呈正相关（每增加 500 克，HR 为 1.12，95%CI 为 1.05-1.20）。出生体重、儿童 BMI 和身高与男性和女性的 RCC 风险呈正相关。
