Mei Shuangshuang, Chen Xing, Wang Kai, Chen Yuxin
Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Xi Men Road, Taizhou, 317000, Zhejiang, China.
Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University (Enze Hospital, Taizhou Enze Medical Center Group), Tong Yang Road, Taizhou, 318053, Zhejiang, China.
Cancer Cell Int. 2023 Jan 25;23(1):11. doi: 10.1186/s12935-023-02854-5.
Ovarian cancer (OC) is one of the most common gynecological malignancies with high morbidity and mortality. The peritoneum is one of the most common metastatic sites in ovarian cancer, involving large amounts of ascites. However, its mechanism is unclear. The peritoneal microenvironment composed of peritoneal effusion and peritoneum creates favorable conditions for ovarian cancer progression and metastasis. Here, we reviewed the peritoneal metastasis patterns and molecular mechanisms of ovarian cancer, as well as major components of the peritoneal microenvironment, peritoneal effusion, and immune microenvironment, and investigated the relationship between the peritoneal microenvironment and ovarian cancer metastasis.
卵巢癌（OC）是最常见的妇科恶性肿瘤之一，发病率和死亡率都很高。腹膜是卵巢癌最常见的转移部位之一，常伴有大量腹水。然而，其机制尚不清楚。由腹腔积液和腹膜组成的腹膜微环境为卵巢癌的进展和转移创造了有利条件。在此，我们综述了卵巢癌的腹膜转移模式和分子机制，以及腹膜微环境、腹腔积液和免疫微环境的主要成分，并探讨了腹膜微环境与卵巢癌转移之间的关系。
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