cAMP/PKA/CREB 和 TGFβ/SMAD4 通路调节结直肠癌细胞的干性和转移潜能。
The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells.
机构信息
Division of Pathophysiology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan.
出版信息
Cancer Res. 2022 Nov 15;82(22):4179-4190. doi: 10.1158/0008-5472.CAN-22-1369.
Abstract
This study identifies signaling pathways essential for maintaining the stemness and metastatic potential of colorectal cancer cells and proposes CREB as a therapeutic target in metastatic colorectal cancer.
摘要
本研究确定了维持结直肠癌细胞干性和转移潜能所必需的信号通路，并提出 CREB 作为转移性结直肠癌的治疗靶点。
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