先前两次脊髓照射后复发性椎体转移瘤的再照射：一例报告。
Re-irradiation of recurrent vertebral metastasis after two previous spinal cord irradiation: A case report.
作者信息
Bentahila Rita, Kinj Rémy, Huck Constance, El Houat Yasmine, Mampuya Ange, Tuleasca Constantin, Ozsahin Mahmut, Bourhis Jean, Schiappacasse Luis
机构信息
Department of Radiation Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Department of Neurosurgery, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
出版信息
Front Oncol. 2023 Jan 5;12:995376. doi: 10.3389/fonc.2022.995376. eCollection 2022.
BACKGROUND
Management of a recurrent vertebral metastasis in a situation of previously irradiated spinal cord is a challenging clinical dilemma.
CASE PRESENTATION
We report a first case of second retreatment of a spinal metastasis initially irradiated with standard radiotherapy and stereotactic body radiation therapy (SBRT), who subsequently progressed with imaging-confirmed local tumor progression at the same level. After a third course of irradiation with SBRT, a complete response was achieved. After 8 months of follow-up, the patients remain free of local recurrence.
CONCLUSION
A third course of vertebral irradiation for a recurrent vertebral metastasis failing to two previous irradiations, in this particular case, have shown the feasibility and efficacy of the technique as a salvage treatment option. This approach could be used in a selected group of patient if an adequate dose is delivered to the target while observing critical tissue tolerance limits.
背景
在先前已接受脊髓照射的情况下，复发性椎体转移瘤的治疗是一个具有挑战性的临床难题。
病例报告
我们报告了首例脊髓转移瘤患者，该患者最初接受了标准放疗和立体定向体部放疗（SBRT），随后影像学证实肿瘤在同一水平局部进展。在接受第三次SBRT照射后，实现了完全缓解。经过8个月的随访，患者未出现局部复发。
结论
在该特定病例中，对于先前两次照射失败的复发性椎体转移瘤进行第三次椎体照射，已显示出该技术作为挽救治疗选择的可行性和有效性。如果在观察关键组织耐受限度的同时向靶区给予足够剂量，这种方法可用于特定的患者群体。
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